Mitochondrial Biology and Experimental Therapeutics

Editors: Oliveira, Paulo J. (Ed.)

  • Combines basic research with commercial applications so that the reader can understand the complete process of developing molecules that target mitochondriaIllustrates the role of mitochondria in cell life and cell death in relation to a variety of diseases through the use of illustrative comics in Chapter
  • Discusses the most current issues and advances in the research of mitochondrial-targeted agents and drug therapy
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eBook $219.00
price for USA in USD (gross)
  • ISBN 978-3-319-73344-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-3-319-73343-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.

About the authors

Paulo J. Oliveira is recognized for his work as the Coordinator of the Mitochondrial, Metabolism, and Disease Group at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal and is the current Vice-President of the European Society of Clinical Investigation (ESCI). He has previously spent some time at the University of Minnesota Medical School, Duluth, investigating the mitochondrial mechanisms of anthracycline-induced selective cardiotoxicity. Throughout his career, he has been involved in projects in which the objective was to advance fundamental knowledge and methodological aspects of mitochondrial research. His current research interests include the role of mitochondria in cardiovascular and liver diseases, the relationship between mitochondrial remodeling and (cancer) stem cell biology, development of novel mitochondrial-targeted therapeutics, as well as the mechanisms of drug-related mitochondrial toxicity. Dr. Oliveira has co-authored close to 200 publications focusing on mitochondrial research.

Table of contents (29 chapters)

  • Introduction: Mitochondria, the Cell Furnaces

    Oliveira, Paulo J.

    Pages 3-9

  • Mitochondria: Where Are They Coming From?

    Esposti, Mauro Degli

    Pages 11-17

  • Mitochondrial Dynamics: A Journey from Mitochondrial Morphology to Mitochondrial Function and Quality

    Sebastián, David (et al.)

    Pages 19-31

  • Mitochondria and Ageing

    Viña, Jose (et al.)

    Pages 33-45

  • The Mitochondrial Permeability Transition Pore

    Morganti, Claudia (et al.)

    Pages 47-73

Buy this book

eBook $219.00
price for USA in USD (gross)
  • ISBN 978-3-319-73344-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-3-319-73343-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mitochondrial Biology and Experimental Therapeutics
Editors
  • Paulo J. Oliveira
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-73344-9
DOI
10.1007/978-3-319-73344-9
Hardcover ISBN
978-3-319-73343-2
Edition Number
1
Number of Pages
IX, 708
Number of Illustrations and Tables
21 b/w illustrations, 106 illustrations in colour
Topics