Accelerated Path to Cures

Editors: Bassaganya-Riera, Josep (Ed.)

  • Details the role of modeling and computational approaches in precision medicine
  • Highlights the progress towards precision medicine
  • Advances Path to Cures
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eBook $59.99
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  • ISBN 978-3-319-73238-1
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Hardcover $79.00
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  • ISBN 978-3-319-73237-4
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About this book

Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures. 

About the authors

Dr. Josep Bassaganya-Riera is a serial entrepreneur and innovator who has served as the Director of the Nutritional Immunology and Molecular Medicine Laboratory (NIMML) at the Biocomplexity Institute of Virginia Tech since 2002. The NIMML tackles unsolved challenges in complex human diseases with unmet clinical needs. His research has received over $55 million in competitive R&D funding to combine advanced computational technologies with preclinical and clinical experimentation. The NIMML translates novel scientific discoveries into commercial applications that address unmet patient or consumer needs. Dr. Bassaganya-Riera has published over 150 peer-reviewed publications in reputable biomedical journals, founded 3 successful biotech companies (Pervida, Biotherapeutics and Landos Biopharma), and was recently named 2017 Innovator of the Year by the Roanoke-Blacksburg Technology Council. Dr. Bassaganya-Riera, and his companies have been active members of a statewide group that supports the planning behind the Governor’s 2015 Virginia Bioscience Initiative.  This initiative calls for Virginia to be in the top three pharmaceutical regions by 2023. Dr. Bassaganya-Riera was a featured presenter at the Governor’s Forum on Bio and Big Data.

Table of contents (5 chapters)

  • Introduction to Accelerated Path to Cures and Precision Medicine in Inflammatory Bowel Disease

    Bassaganya-Riera, Josep (et al.)

    Pages 1-6

  • Computer-Aided Drug Discovery

    Lu, Pinyi (et al.)

    Pages 7-24

  • Preclinical Studies: Efficacy and Safety

    Tubau-Juni, Nuria (et al.)

    Pages 25-40

  • From Nutritional Immunology to Drug Development

    Verma, Meghna (et al.)

    Pages 41-56

  • Development of Synthetic Patient Populations and In Silico Clinical Trials

    Zand, Ramin (et al.)

    Pages 57-77

Buy this book

eBook $59.99
price for USA in USD (gross)
  • ISBN 978-3-319-73238-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $79.00
price for USA in USD
  • ISBN 978-3-319-73237-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Accelerated Path to Cures
Editors
  • Josep Bassaganya-Riera
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-73238-1
DOI
10.1007/978-3-319-73238-1
Hardcover ISBN
978-3-319-73237-4
Edition Number
1
Number of Pages
VIII, 82
Number of Illustrations and Tables
11 illustrations in colour
Topics