Recombinant Antibodies for Infectious Diseases

1. Front Matter

   Pages i-xviii

   PDF

2. Filamentous Phage: Structure and Biology

   • Jasna Rakonjac, Marjorie Russel, Sofia Khanum, Sam J. Brooke, Marina Rajič

   Pages 1-20

3. Antibody Phage Display

   • Hyunbo Shim

   Pages 21-34

4. Naïve Human Antibody Libraries for Infectious Diseases

   • Soo Khim Chan, Anizah Rahumatullah, Jing Yi Lai, Theam Soon Lim

   Pages 35-59

5. Immune Human Antibody Libraries for Infectious Diseases

   • Soo Khim Chan, Theam Soon Lim

   Pages 61-78

6. Synthetic Antibodies in Infectious Disease

   • Gang Chen, Sachdev S. Sidhu, Johan Nilvebrant

   Pages 79-98

7. Monoclonal Antibodies and Antibody Like Fragments Derived from Immunised Phage Display Libraries

   • Obinna Ubah, Soumya Palliyil

   Pages 99-117

8. Anti-bacterial Monoclonal Antibodies

   • Eszter Nagy, Gábor Nagy, Christine A. Power, Adriana Badarau, Valéria Szijártó

   Pages 119-153

9. Anti-parasitic Antibodies from Phage Display

   • Luiz R. Goulart, Vanessa da S. Ribeiro, Julia M. Costa-Cruz

   Pages 155-171

10. Therapeutic Antibodies for Biodefense

    • Arnaud Avril

    Pages 173-205

11. Engineering Antibodies for the Treatment of Infectious Diseases

    • Gaowei Fan, Jinming Li

    Pages 207-220

12. Computer-Aided Antibody Design: An Overview

    • Yee Siew Choong, Yie Vern Lee, Jia Xin Soong, Cheh Tat Law, Yee Ying Lim

    Pages 221-243

13. Using High-Throughput Sequencing to Characterize the Development of the Antibody Repertoire During Infections: A Case Study of HIV-1

    • Felix Breden, Corey T. Watson

    Pages 245-263

14. Safety and General Considerations for the Use of Antibodies in Infectious Diseases

    • Adam Seidelin Hey

    Pages 265-294

15. Back Matter

    Pages 295-296

    PDF

There are many principles and applications of recombinant antibodies for infectious diseases. The preferred technology associated to recombinant antibody generation is mainly phage display. The adaptation of antibodies for infectious diseases is an area lacking information as most literature is focused on oncology or autoimmunity. This project highlights the power and potential of antibody phage display for infectious diseases. In addition to that, supplementary information regarding technologies associated to antibody generation and engineering in the context of infectious disease will also help to provide greater insight to the potential of recombinant antibodies for infectious diseases.

• Antibody Phage Display
• Antibody Library
• Synthetic Antibody
• Immunized Antibody
• Infectious Diseases
• antibodies

• Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang, Malaysia

  Theam Soon Lim

Theam Soon Lim is a researcher, senior lecturer and group leader at the Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia (USM) in Penang, Malaysia. Theam Soon has spent the last decade honing his skills and knowledge in the field of antibody phage display with a special interest in infectious diseases. Theam Soon obtained his doctoral degree at Max Planck Institute for Molecular Genetics in 2009 studying the factors involved in antibody presentation on phage particles. Since then, he has returned to his home country of Malaysia to continue his work on antibody phage display. He is responsible for the setting up of the recombinant antibody technology laboratory at INFORMM, USM as part of the national initiative by the Malaysian Ministry of Higher Education under the Higher Institution Centres of Excellence program. His group has been active in the development of several antibody phage libraries focusing on naïve and immune repertoires for infectious diseases. His side passion includes the development of affordable biosensor systems using recombinant antibodies and oligonucleotides. He now serves as the Deputy Director of the institute and is based in Penang, Malaysia.

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