A Clinician's Guide to Sperm DNA and Chromatin Damage

Editors: Zini, Armand, Agarwal, Ashok (Eds.)

  • A comprehensive, up-to date guide to sperm DNA and chromatic damage for the clinician treating the infertile maleSections cover sperm chromatin structure, lab evaluation of chromatin and DNA damage, biological and clinical factors, clinical studies on the utility of sperm DNA damage testing, and current treatment options
  • An excellent resource for reproductive medicine and REI specialists, urologists and any professional working with the infertile male
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eBook $219.00
price for USA in USD (gross)
  • ISBN 978-3-319-71815-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-3-319-71814-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This comprehensive, up-to-date text, which brings together the key practical elements of the rapidly evolving field of sperm DNA and chromatin abnormalities, is divided thematically into five main sections. Part I discusses human sperm chromatin structure and nuclear architecture, while part II presents laboratory evaluation of sperm DNA damage, including SCSA, SCD, TUNEL and Comet assays, and cytochemical tests. Biological and clinical factors in the etiology of sperm DNA damage are discussed in part III, including oxidative stress, abortive apoptosis, cancer, and environmental and lifestyle factors. Part IV presents clinical studies on the utility of sperm DNA damage tests, both with natural and ART-assisted pregnancies, and debates the clinical utility of such tests. Finally, part V discusses current treatment options, such as antioxidant therapy, varicocelectomy, advanced sperm processing techniques and the use of testicular sperm.

We are now beginning to better understand the unique organization of the sperm chromatin, as well as the nature and etiology of sperm DNA damage. Written and edited by worldwide experts in andrology, A Clinician's Guide to Sperm DNA and Chromatin Damage is an excellent resource for reproductive medicine and REI specialists, urologists, reproductive biologists and any professional working with the infertile male.

About the authors

Armand Zini, MD, FRCSC, Professor, Department of Surgery, Division of Urology, St. Mary’s Hospital Center, Montreal, Québec, Canada

Ashok Agarwal, PhD, HCLD, Professor, Lerner College of Medicine of Case Western Reserve University, Director, Andrology Center, Director, American Center for Reproductive Medicine, Department of Urology, Cleveland Clinic Foundation, Cleveland, Ohio, USA

Table of contents (32 chapters)

  • Sperm Chromatin: An Overview

    Balhorn, Rod

    Pages 3-30

  • Sperm Nucleoproteins (Histones and Protamines)

    Barrachina, Ferran (et al.)

    Pages 31-51

  • Sperm Nuclear Architecture

    Ward, W. Steven

    Pages 53-61

  • Sperm Chromatin Structure Assay (SCSA®): Evolution from Origin to Clinical Utility

    Evenson, Donald P.

    Pages 65-89

  • TUNEL Assay

    Muratori, Monica (et al.)

    Pages 91-102

Buy this book

eBook $219.00
price for USA in USD (gross)
  • ISBN 978-3-319-71815-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $279.99
price for USA in USD
  • ISBN 978-3-319-71814-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
A Clinician's Guide to Sperm DNA and Chromatin Damage
Editors
  • Armand Zini
  • Ashok Agarwal
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-71815-6
DOI
10.1007/978-3-319-71815-6
Hardcover ISBN
978-3-319-71814-9
Edition Number
1
Number of Pages
XIX, 605
Topics