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Methods and Biostatistics in Oncology

Understanding Clinical Research as an Applied Tool

Editors: Araújo, Raphael. L.C, Riechelmann, Rachel P. (Eds.)

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  • A tailor-made book on clinical research and biostatistics in oncology
  • Focuses on practical and applicable knowledge and usefulness in daily practice, allowing readers to properly appraise literature
  • All chapters and examples are contextualized to oncology
  • Intended for surgical and clinical oncologists, researchers, students and professors in the field
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  • ISBN 978-3-319-71324-3
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  • ISBN 978-3-319-71323-6
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About this book

This book introduces and discusses the most important aspects of clinical research methods and biostatistics for oncologists, pursuing a tailor-made and practical approach. Evidence-based medicine (EBM) has been in vogue in the last few decades, particularly in rapidly advancing fields such as oncology. This approach has been used to support decision-making processes worldwide, sparking new clinical research and guidelines on clinical and surgical oncology. Clinical oncology research has many peculiarities, including specific study endpoints, a special focus on survival analyses, and a unique perspective on EBM. However, during medical studies and in general practice, these topics are barely taught. Moreover, even when EBM and clinical cancer research are discussed, they are presented in a theoretical fashion, mostly focused on formulas and numbers, rather than on clinical application for a proper literature appraisal. Addressing that gap, this book discusses more practical aspects of clinical research and biostatistics in oncology, instead of relying only on mathematical formulas and theoretical considerations. Methods and Biostatistics in Oncology will help readers develop the skills they need to understand the use of research on everyday oncology clinical practice for study design and interpretation, as well to demystify the use of EBM in oncology.

About the authors

Raphael L. C. Araujo is a Surgical Oncologist specialized in the diagnosis and treatment of malignant and benign injuries of the liver, pancreas and colorectal liver metastases. He spent two years (2010 / 2012) as a Research Fellow at the Hepatopancreatobiliary Service of the Memorial Sloan-Kettering Cancer Center in New York (USA). During this time, he worked on clinical research of surgical and systemic treatment of pancreatic cancer and colorectal liver metastases. Afterwards, he also spent one year as a resident of the Hepatopancreatobiliary Service at the Hospital Paul Brousse, France (2012/2013). Dr. Araujo received a PhD and concluded his postdoctoral research in Gastroenterology from the University of São Paulo School of Medicine, the same institution where he worked for 2 years as an attending physician in the Liver Surgery Unit. He is currently head of the Department of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery and Professor of the Post Graduation Program of Barretos Cancer Hospital, Barretos, São Paulo, Brazil, and Scientific Director of Brazilian Society of Surgical Oncology.

Rachel P. Riechelmann is a medical oncologist and researcher in the field of gastrointestinal cancers. She completed her formal training and PhD at the Federal University of Sao Paulo, followed by a clinical research fellowship at Princess Margaret Hospital, University of Toronto, Canada. She is currently the Director of the Department of Oncology at AC Camargo Cancer Center,  which is one of the largest academic cancer centers in Brazil and Latin America, and Research Director of the Brazilian Gastrointestinal Tumors Group. Research- wise, her areas of interest and expertise are GI malignancies and Neuroendocrine Tumors as well as Methodology of Clinical Research. She has 78 publications in peer-reviewed journals and several PhD students and oncology fellows conducting projects under her supervision. 

Table of contents (20 chapters)

Table of contents (20 chapters)
  • Brief History of the Scientific Method and Its Application in Oncology

    Lima Vazquez, Vinicius, M.D., Ph.D. (et al.)

    Pages 1-8

  • Generating a Hypothesis for an Oncology Study

    Costa, Beatriz Teixeira (et al.)

    Pages 9-22

  • Types of Variables and Distributions

    Pond, Gregory R., Ph.D., P.Stat. (et al.)

    Pages 23-35

  • Testing Measures of Associations

    Paolino, Bruno S., M.D., Ph.D. (et al.)

    Pages 37-49

  • Sample Size Calculation in Oncology Studies

    Riechelmann, Rachel P., M.D., Ph.D. (et al.)

    Pages 51-69

Buy this book

eBook n/a
  • ISBN 978-3-319-71324-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
Hardcover n/a
  • ISBN 978-3-319-71323-6
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Methods and Biostatistics in Oncology
Book Subtitle
Understanding Clinical Research as an Applied Tool
Editors
  • Raphael. L.C Araújo
  • Rachel P. Riechelmann
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-71324-3
DOI
10.1007/978-3-319-71324-3
Hardcover ISBN
978-3-319-71323-6
Edition Number
1
Number of Pages
XII, 348
Number of Illustrations
21 b/w illustrations, 37 illustrations in colour
Topics