Current Topics in Microbiology and Immunology

Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity

Editors: Yoshimura, Akihiko (Ed.)

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  • Addresses all aspects of the molecular and cellular biology of extracellular and intracellular immune checkpoint regulators
  • Promotes the understanding and application of extended immune checkpoint regulators
  • Offers new strategies for the therapy of various diseases, such as autoimmune diseases and cancer
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eBook $169.00
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  • ISBN 978-3-319-68929-6
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Hardcover $219.99
price for USA in USD
  • ISBN 978-3-319-68928-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
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  • ISBN 978-3-319-88684-8
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About this book

This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases.

Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.

About the authors

Akihiko Yoshimura, PhD
Department of Microbiology and Immunology,
Keio University School of Medicine
35 Shinanomachi, Shinjyuku-ku, Tokyo
160-8582, Japan
Phone: +81-3-5363-3483
FAX: +81-3-5360-1508

yoshimura@a6.keio.jp

Table of contents (11 chapters)

Table of contents (11 chapters)
  • Regulatory T Cells: Molecular and Cellular Basis for Immunoregulation

    Togashi, Yosuke (et al.)

    Pages 3-27

  • Overview of LAG-3-Expressing, IL-10-Producing Regulatory T Cells

    Fujio, Keishi (et al.)

    Pages 29-45

  • Regulatory Dendritic Cells

    Sato, Katsuaki (et al.)

    Pages 47-71

  • Role of PD-1 in Immunity and Diseases

    Chamoto, Kenji (et al.)

    Pages 75-97

  • CTLA-4, an Essential Immune-Checkpoint for T-Cell Activation

    Chikuma, Shunsuke

    Pages 99-126

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-3-319-68929-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-3-319-68928-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-3-319-88684-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity
Editors
  • Akihiko Yoshimura
Series Title
Current Topics in Microbiology and Immunology
Series Volume
410
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-68929-6
DOI
10.1007/978-3-319-68929-6
Hardcover ISBN
978-3-319-68928-9
Softcover ISBN
978-3-319-88684-8
Series ISSN
0070-217X
Edition Number
1
Number of Pages
VIII, 267
Topics