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Resistance to Targeted Anti-Cancer Therapeutics
cover

Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways

Editors: Yarden, Yosef, Elkabets, Moshe (Eds.)

  • Comprehensively covers the multiplicity and diversity of mechanisms underlying resistance to the currently approved drugs, both tyrosine kinase inhibitors and monoclonal antibodies, that specifically inhibit growth factor receptors playing driver or survival functions in cancerExamines specific targets and the cognate drugsEvaluates molecular modes of innate and evolving resistance

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eBook $149.00
price for USA in USD (gross)
  • ISBN 978-3-319-67932-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-3-319-67930-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.99
price for USA in USD
  • ISBN 978-3-030-09817-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression. Each chapter will cover a specific group of targets and the cognate drugs, along with molecular modes of innate and evolving resistance.

About the authors

Yosef Yarden, PhD, is Professor, Department of Biological Regulation, The Weizmann Institute of Science, Israel.

Table of contents (9 chapters)

Table of contents (9 chapters)
  • Resistance of Colorectal Tumors to Anti-EGFR Antibodies

    Pages 1-27

    Trusolino, Livio (et al.)

  • Resistance of Lung Cancer to Kinase Inhibitors Specific to EGFR or ALK

    Pages 29-49

    Mancini, Maicol (et al.)

  • Mechanisms of Action and Resistance of Trastuzumab in Breast Cancer

    Pages 51-66

    Hsu, Jennifer L. (et al.)

  • Mechanisms of Resistance to Molecular Therapies Targeting the HGF/MET Axis

    Pages 67-87

    Corso, Simona (et al.)

  • RAF, MEK and ERK Inhibitors as Anti-Cancer Drugs: Intrinsic and Acquired Resistance as a Major Therapeutic Challenge

    Pages 89-116

    Maik-Rachline, Galia (et al.)

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-3-319-67932-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-3-319-67930-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.99
price for USA in USD
  • ISBN 978-3-030-09817-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways
Editors
  • Yosef Yarden
  • Moshe Elkabets
Series Title
Resistance to Targeted Anti-Cancer Therapeutics
Series Volume
15
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-67932-7
DOI
10.1007/978-3-319-67932-7
Hardcover ISBN
978-3-319-67930-3
Softcover ISBN
978-3-030-09817-9
Series ISSN
2196-5501
Edition Number
1
Number of Pages
XX, 242
Number of Illustrations
22 illustrations in colour
Topics