A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment

Editors: Garcia-Reyero, Natàlia, Murphy, Cheryl (Eds.)

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  • First book to explore different aspects of systems biology and their application to the development of the adverse outcome pathway frameworkCombines all computational and molecular tools together for applicationsBridges multiple scales of biological organization,beyond the organism to include population level effects

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  • ISBN 978-3-319-66084-4
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Hardcover $249.99
price for USA in USD
  • ISBN 978-3-319-66082-0
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Softcover $159.99
price for USA in USD
  • ISBN 978-3-030-09758-5
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  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
About this book

Social pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. While past efforts have focused on toxicological pathway-based vision for human and ecological health assessment relying on in vitro systems and predictive models, The Adverse Outcome Pathway framework provides a simplified and structured way to organize toxicological information. Within the book, a systems biology approach supplies the tools to infer, link, and quantify the molecular initiating events and the key events and key event relationships leading to adverse outcomes. The advancement of these tools is crucial for the successful implementation of AOPs for regulatory purposes.

About the authors

Natàlia Garcia-Reyero Vinas received her BS in Biology from Universitat de Girona, and her MS and PhD from Universitat de Barcelona, in Barcelona, Spain. She is now a researcher at the US Army Engineer Research & Development Center Environmental Laboratory. Her research focuses on environmental pollutants and their effects on aquatic species while trying to elucidate their mechanisms of action using ecotoxicogenomics and a systems biology approach.

Cheryl A. Murphy received her BSc in Marine Biology from Dalhousie University, Canada, her MSc in Physiology and Cell Biology from University of Alberta, Canada and PhD in Oceanography and Coastal Sciences from Louisiana State University. She is now an Associate Professor at Michigan State University, in the Department of Fisheries and Wildlife. Her research focuses on environmental pollutants and stressors and their effects on aquatic species while trying to link subtle molecular and subcellular responses to population relevant endpoints that are crucial for ecological risk assessment. 

Table of contents (19 chapters)

Table of contents (19 chapters)
  • Advancing Adverse Outcome Pathways for Risk Assessment

    Pages 1-14

    Garcia-Reyero, Natàlia (et al.)

  • Use of High-Throughput and Computational Approaches for Endocrine Pathway Screening

    Pages 15-29

    Browne, Patience (et al.)

  • Cell-Free Assays in Environmental Toxicology

    Pages 31-41

    Arini, Adeline (et al.)

  • The Fish Embryo as a Model for AOP Development

    Pages 43-73

    Vergauwen, Lucia (et al.)

  • Invertebrate Model Species in AOP Development

    Pages 75-106

    Hodges, Geoff (et al.)

Buy this book

eBook $119.00
price for USA in USD
  • ISBN 978-3-319-66084-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-319-66082-0
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $159.99
price for USA in USD
  • ISBN 978-3-030-09758-5
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment
Editors
  • Natàlia Garcia-Reyero
  • Cheryl Murphy
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-66084-4
DOI
10.1007/978-3-319-66084-4
Hardcover ISBN
978-3-319-66082-0
Softcover ISBN
978-3-030-09758-5
Edition Number
1
Number of Pages
XIV, 422
Number of Illustrations
13 b/w illustrations, 64 illustrations in colour
Topics