Skip to main content
SpringerLink
Log in

A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment

  • Book
  • © 2018

Overview

Editors:
  1. Natàlia Garcia-Reyero

    1. Environmental Laboratory, US Army Engineer Research & Development Center, Vicksburg, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Cheryl A. Murphy

    1. Department of Fisheries and Wildlife, Michigan State University, East Lansing, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • First book to explore different aspects of systems biology and their application to the development of the adverse outcome pathway framework

  • Combines all computational and molecular tools together for applications

  • Bridges multiple scales of biological organization,beyond the organism to include population level effects

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (19 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Advancing Adverse Outcome Pathways for Risk Assessment

    • Natàlia Garcia-Reyero, Cheryl A. Murphy
    Pages 1-14

  3. Use of High-Throughput and Computational Approaches for Endocrine Pathway Screening

    • Patience Browne, Warren M. Casey, David J. Dix
    Pages 15-29

  4. Cell-Free Assays in Environmental Toxicology

    • Adeline Arini, Krittika Mittal, Niladri Basu
    Pages 31-41

  5. The Fish Embryo as a Model for AOP Development

    • Lucia Vergauwen, Steven Van Cruchten, Dries Knapen
    Pages 43-73

  6. Invertebrate Model Species in AOP Development

    • Geoff Hodges, Steve Gutsell, Nadine Taylor, Erica Brockmeier, Emma Butler, Cecilie Rendal et al.
    Pages 75-106

  7. Non-model Species in Ecological Risk Assessment

    • Markus Hecker
    Pages 107-132

  8. Green Algae and Networks for Adverse Outcome Pathways

    • Anze Zupanic, Smitha Pillai, Diana Coman Schmid, Kristin Schirmer
    Pages 133-148

  9. Neurobehavioral Analysis Methods for Adverse Outcome Pathway (AOP) Models and Risk Assessment

    • Francisco X. Mora-Zamorano, Jeremy K. Larson, Michael J. Carvan III
    Pages 149-175

  10. The Application of Omics Data to the Development of AOPs

    • Mary T. McBride
    Pages 177-198

  11. Use of Genetic Manipulation for Evaluating and Understanding Adverse Outcome Pathways

    • Christopher Warner, Natàlia Garcia-Reyero, Edward Perkins
    Pages 199-218

  12. Considering Epigenetics in Adverse Outcome Pathways

    • Kristine L. Willett
    Pages 219-234

  13. Tiered Approaches to Incorporate the Adverse Outcome Pathway Framework into Chemical-Specific Risk-Based Decision Making

    • Jeremy Leonard, Shannon Bell, Noffisat Oki, Mark Nelms, Yu-Mei Tan, Stephen Edwards
    Pages 235-261

  14. The Development of Quantitative AOPs

    • Irvin R. Schultz, Karen H. Watanabe
    Pages 263-280

  15. Linking Adverse Outcome Pathways to Dynamic Energy Budgets: A Conceptual Model

    • Cheryl A. Murphy, Roger M. Nisbet, Philipp Antczak, Natàlia Garcia-Reyero, Andre Gergs, Konstadia Lika et al.
    Pages 281-302

  16. Weight of Evidence Frameworks in Evaluation of Adverse Outcome Pathways

    • Taylor Rycroft, Olivia Massey, Christy M. Foran, Igor Linkov
    Pages 303-316

  17. Using a Vitellogenesis Model to Link in vitro Neurochemical Effects of Pulp and Paper Mill Effluents to Adverse Reproductive Outcomes in Fish

    • Brandon M. Armstrong, Cheryl A. Murphy, Niladri Basu
    Pages 317-347

  18. Use of Adverse Outcome Pathways in Human Risk Assessment and Toxicology

    • Catherine Willett, Suzanne Fitzpatrick, Bette Meek, Carl Westmoreland
    Pages 349-378

  19. Use and Acceptance of AOPs for Regulatory Applications

    • Clemens Wittwehr
    Pages 379-390

  20. The Future of Adverse Outcome Pathways: Analyzing their Social Context

    • Kevin C. Elliott, Cheryl A. Murphy, Natàlia Garcia-Reyero
    Pages 391-404
Back to top

Keywords

About this book

Social pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. While past efforts have focused on toxicological pathway-based vision for human and ecological health assessment relying on in vitro systems and predictive models, The Adverse Outcome Pathway framework provides a simplified and structured way to organize toxicological information. Within the book, a systems biology approach supplies the tools to infer, link, and quantify the molecular initiating events and the key events and key event relationships leading to adverse outcomes. The advancement of these tools is crucial for the successful implementation of AOPs for regulatory purposes.

Editors and Affiliations

  • Environmental Laboratory, US Army Engineer Research & Development Center, Vicksburg, USA

    Natàlia Garcia-Reyero

  • Department of Fisheries and Wildlife, Michigan State University, East Lansing, USA

    Cheryl A. Murphy

About the editors

Natàlia Garcia-Reyero Vinas received her BS in Biology from Universitat de Girona, and her MS and PhD from Universitat de Barcelona, in Barcelona, Spain. She is now a researcher at the US Army Engineer Research & Development Center Environmental Laboratory. Her research focuses on environmental pollutants and their effects on aquatic species while trying to elucidate their mechanisms of action using ecotoxicogenomics and a systems biology approach.


Cheryl A. Murphy received her BSc in Marine Biology from Dalhousie University, Canada, her MSc in Physiology and Cell Biology from University of Alberta, Canada and PhD in Oceanography and Coastal Sciences from Louisiana State University. She is now an Associate Professor at Michigan State University, in the Department of Fisheries and Wildlife. Her research focuses on environmental pollutants and stressors and their effects on aquatic species while trying to link subtle molecular and subcellular responses to population relevant endpoints that are crucial for ecological risk assessment. 


Bibliographic Information

  • Book Title: A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment

  • Editors: Natàlia Garcia-Reyero, Cheryl A. Murphy

  • DOI: https://doi.org/10.1007/978-3-319-66084-4

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG 2018

  • Hardcover ISBN: 978-3-319-66082-0Published: 08 March 2018

  • Softcover ISBN: 978-3-030-09758-5Published: 30 January 2019

  • eBook ISBN: 978-3-319-66084-4Published: 24 February 2018

  • Edition Number: 1

  • Number of Pages: XIV, 422

  • Number of Illustrations: 13 b/w illustrations, 64 illustrations in colour

  • Topics: Systems Biology, Pharmacology/Toxicology

Publish with us

Policies and ethics

Back to top

Search

Navigation