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Self-Assembled Molecules – New Kind of Protein Ligands

Supramolecular Ligands

Editors: Roterman, Irena, Konieczny, Leszek (Eds.)

  • An up-to-date account of supramolecular ligands
  • Essential reading for academic and industrial scientists interested in drug targeting
  • A comprehensive overview of the enhancement of immune complexation
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eBook  
  • ISBN 978-3-319-65639-7
  • This book is an open access book, you can download it for free on link.springer.com
Hardcover $59.99
price for USA in USD
  • ISBN 978-3-319-65638-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $59.99
price for USA in USD
  • ISBN 978-3-319-88071-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The subject of this book relates to protein ligands with particular structural and complexation properties. They are composed of self-assembled molecules, capable of penetrating as a unit into proteins outside the binding site. The ribbon-like supramolecular system only permits the penetration of self-assembled molecules into the protein-body and formation of stable complexes. Supramolecular Congo red and similar compounds fit these requirements. Destabilized protein fragments enable the penetration of such ligands, with susceptibility to supramolecular ligand binding often associated with protein function. As a result, complexation modifies their functional effects. The activity of enzymes is inhibited by arresting them in the complexed state, but “naturally irreversible” complexation as in the case of immune complexation, is enhanced instead. This property offers many attractive possibilities of using supramolecular ligands as described in this book. This book is an open access under a CC BY license. 

About the authors

Dr Irena Roterman-Konieczna – professor of bioinformatics  heads the bioinformatics group at the Jagiellonian University – Medical College and the Faculty of Physics, Astronomy and Applied Computer Science, Poland. Her background is the theoretical chemistry and her research focuses on bioinformatics with a special focus on protein structure prediction. Involved also in education of medical students and students of computer science developing different forms of simulations in medicine.

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Table of contents (8 chapters)

Table of contents (8 chapters)
  • Supramolecular Systems as Protein Ligands

    Rybarska, Joanna (et al.)

    Pages 1-20

  • Supramolecular Congo Red as Specific Ligand of Antibodies Engaged in Immune Complex

    Jagusiak, Anna (et al.)

    Pages 21-41

  • Protein Conditioning for Binding Congo Red and Other Supramolecular Ligands

    Zemanek, Grzegorz (et al.)

    Pages 43-60

  • Metal Ions Introduced to Proteins by Supramolecular Ligands

    Woźnicka, Olga (et al.)

    Pages 61-76

  • Possible Mechanism of Amyloidogenesis of V Domains

    Banach, Mateusz (et al.)

    Pages 77-100

Buy this book

eBook  
  • ISBN 978-3-319-65639-7
  • This book is an open access book, you can download it for free on link.springer.com
Hardcover $59.99
price for USA in USD
  • ISBN 978-3-319-65638-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $59.99
price for USA in USD
  • ISBN 978-3-319-88071-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Self-Assembled Molecules – New Kind of Protein Ligands
Book Subtitle
Supramolecular Ligands
Editors
  • Irena Roterman
  • Leszek Konieczny
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
The Editor(s) (if applicable) and The Author(s)
eBook ISBN
978-3-319-65639-7
DOI
10.1007/978-3-319-65639-7
Hardcover ISBN
978-3-319-65638-0
Softcover ISBN
978-3-319-88071-6
Edition Number
1
Number of Pages
XII, 136
Number of Illustrations
54 b/w illustrations, 44 illustrations in colour
Topics