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Precision Molecular Pathology of Prostate Cancer

  • Book
  • © 2018

Overview

Editors:
  1. Brian D. Robinson

    1. Pathology and Laboratory Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, USA

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  2. Juan Miguel Mosquera

    1. Pathology and Laboratory Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, USA

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  3. Jae Y. Ro

    1. Institute for Academic Medicine, Houston Methodist Hospital Pathology and Genomic Medicine, Weill Medical College of Cornell University, Houston, USA

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  4. Mukul Divatia

    1. Institute for Academic Medicine, Houston Methodist Hospital Pathology and Genomic Medicine, Weill Medical College of Cornell University, Houston, USA

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  • Written by experts in the field
  • Provides the latest information and current insights
  • Comprehensively covers the new molecular pathology of prostate cancer

Part of the book series: Molecular Pathology Library (MPLB)

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Table of contents (30 chapters)

  1. Front Matter

    Pages i-xiv
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  2. General Principles

    1. Front Matter

      Pages 1-1
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    2. Precision Medicine in Prostate Cancer: Approach to the Patient

      • Beerinder S. Karir, Bishoy M. Faltas, Scott T. Tagawa
      Pages 3-12

    3. Epidemiology and Etiology

      • Padraic O’Malley
      Pages 13-26

    4. High-Grade Prostatic Intraepithelial Neoplasia

      • Fadi Brimo
      Pages 27-36

    5. Pathology of Prostate Cancer

      • Shaham Beg, Francesca Khani, Brian D. Robinson
      Pages 37-56

    6. Genetic Susceptibility

      • John P. Greene, Stephen P. Finn
      Pages 57-78

    7. Racial Differences

      • Francesca Khani, Brian D. Robinson
      Pages 79-98

    8. Cancer Stem Cells

      • Yanjing Li, Jiaoti Huang
      Pages 99-113

  3. Molecular Signatures of Primary Prostate Cancer

    1. Front Matter

      Pages 115-115
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    2. Prostate Cancer Risk: Single Nucleotide Polymorphisms (SNPs)

      • Robert J. Klein
      Pages 117-128

    3. Copy Number Variation/Chromosomal Aberration

      • Olivier Elemento
      Pages 129-135

    4. Gene Fusions

      • Andrea Sboner
      Pages 137-151

    5. Gene Expression Analysis

      • Michael Ittmann
      Pages 153-167

    6. Next-Generation Sequencing

      • Anne Offermann, Sven Perner
      Pages 169-192

    7. Epigenetic Alterations in Primary Prostate Cancer

      • Fátima Valdés-Mora, Clare Stirzaker
      Pages 193-211

    8. Proteomics in Prostate Cancer Research

      • Samantha E. T. Larkin, Benjamin Abbott, Michael D. Brown, Thomas R. Jackson, Noel W. Clarke, Paul A. Townsend
      Pages 213-236

    9. Metabolomic-Based Stratification in Prostate Cancer

      • Stefano Cacciatore, Giorgia Zadra, Massimo Loda
      Pages 237-258

    10. Tumor Microenvironment: Prospects for Diagnosis and Prognosis of Prostate Cancer Based on Changes in Tumor-Adjacent Stroma

      • Zhenyu Jia, Chung Lee, Xiaolin Zi, Michael McClelland, Dan Mercola
      Pages 259-275

  4. Molecular Signatures of Advanced Prostate Cancer

    1. Front Matter

      Pages 277-277
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Keywords

About this book

This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches.  The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease.  The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) and Precision medicine approach: Diagnosis, treatment, prognosis.  Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.  

Editors and Affiliations

  • Pathology and Laboratory Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, USA

    Brian D. Robinson, Juan Miguel Mosquera

  • Institute for Academic Medicine, Houston Methodist Hospital Pathology and Genomic Medicine, Weill Medical College of Cornell University, Houston, USA

    Jae Y. Ro, Mukul Divatia

About the editors

Brian D. Robinson, MD
Weill Cornell MedicineNew York, NY
USA

Bibliographic Information

  • Book Title: Precision Molecular Pathology of Prostate Cancer

  • Editors: Brian D. Robinson, Juan Miguel Mosquera, Jae Y. Ro, Mukul Divatia

  • Series Title: Molecular Pathology Library

  • DOI: https://doi.org/10.1007/978-3-319-64096-9

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-64094-5Published: 22 February 2018

  • Softcover ISBN: 978-3-319-87721-1Published: 06 June 2019

  • eBook ISBN: 978-3-319-64096-9Published: 13 February 2018

  • Series ISSN: 1935-987X

  • Series E-ISSN: 1935-9888

  • Edition Number: 1

  • Number of Pages: XIV, 570

  • Number of Illustrations: 2 b/w illustrations, 48 illustrations in colour

  • Topics: Pathology, Oncology, Urology

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