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Advances in Experimental Medicine and Biology

Precision Medicine, CRISPR, and Genome Engineering

Moving from Association to Biology and Therapeutics

Editors: Tsang, Stephen H. (Ed.)

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  • Timely State-of-the-science on CRISPR and gene editing, an exciting and controversial frontier in regenerative medicine
    Contributed by top experts in this rapidly-evolving field
    One of the first books to connect genetically modified foods to this area

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eBook $139.00
price for USA in USD (gross)
  • ISBN 978-3-319-63904-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-319-63903-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-3-319-87667-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine.  Chapters feature contributions from leaders in stem cell therapy and biology, providing a comprehensive view of the application of gene therapy in numerous fields with an emphasis on ophthalmology, stem cells, and agriculture. The book also highlights recent major technological advances, including ZFN, TALEN, and CRISPR. Precision Medicine, CRISPR, and Genome Engineering is part of the highly successful Advances in Experimental Medicine and Biology series. It is an indispensable resource for researchers and students in genetics as well as clinicians. 

About the authors

For years, Stephen Tsang has been culturing embryonic stem (ES) cells and created the first mouse model for a recessive form of retinitis pigmentosa by applying homologous recombination to ES cell technology. Two elements define his laboratory. First, by leveraging his genetics clinical practice, in which over 1000 retinal patients are cared for, he brings an array of clinical resources to his research, including stem cells and live imaging data. Second, he and his students are recognized authorities in a broad array of state-of-the-art technologies. Most recently, he was invited as a Moderator for the Gene Editing/Rewriting the Genome session during the 65th American Society of Human Genetics Annual Meeting.

Table of contents (9 chapters)

Table of contents (9 chapters)
  • Viral Vectors, Engineered Cells and the CRISPR Revolution

    Pages 3-27

    DiCarlo, James E., Ph.D. (et al.)

  • Combining Engineered Nucleases with Adeno-associated Viral Vectors for Therapeutic Gene Editing

    Pages 29-42

    Epstein, Benjamin E. (et al.)

  • From Reductionism to Holism: Toward a More Complete View of Development Through Genome Engineering

    Pages 45-74

    Delker, Rebecca K., Ph.D. (et al.)

  • A Transgenic Core Facility’s Experience in Genome Editing Revolution

    Pages 75-90

    Yuan, Celvie L., Ph.D. (et al.)

  • Genome Editing to Study Ca2+ Homeostasis in Zebrafish Cone Photoreceptors

    Pages 91-100

    Brockerhoff, Susan E., Ph.D.

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-3-319-63904-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-319-63903-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-3-319-87667-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Precision Medicine, CRISPR, and Genome Engineering
Book Subtitle
Moving from Association to Biology and Therapeutics
Editors
  • Stephen H. Tsang
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1016
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-63904-8
DOI
10.1007/978-3-319-63904-8
Hardcover ISBN
978-3-319-63903-1
Softcover ISBN
978-3-319-87667-2
Series ISSN
0065-2598
Edition Number
1
Number of Pages
IX, 178
Number of Illustrations
4 b/w illustrations, 15 illustrations in colour
Topics