Precision Medicine, CRISPR, and Genome Engineering
Moving from Association to Biology and Therapeutics
Editors: Tsang, Stephen H. (Ed.)
Free Preview- Timely State-of-the-science on CRISPR and gene editing, an exciting and controversial frontier in regenerative medicineContributed by top experts in this rapidly-evolving fieldOne of the first books to connect genetically modified foods to this area
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- About this book
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This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine. Chapters feature contributions from leaders in stem cell therapy and biology, providing a comprehensive view of the application of gene therapy in numerous fields with an emphasis on ophthalmology, stem cells, and agriculture. The book also highlights recent major technological advances, including ZFN, TALEN, and CRISPR. Precision Medicine, CRISPR, and Genome Engineering is part of the highly successful Advances in Experimental Medicine and Biology series. It is an indispensable resource for researchers and students in genetics as well as clinicians.
- About the authors
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For years, Stephen Tsang has been culturing embryonic stem (ES) cells and created the first mouse model for a recessive form of retinitis pigmentosa by applying homologous recombination to ES cell technology. Two elements define his laboratory. First, by leveraging his genetics clinical practice, in which over 1000 retinal patients are cared for, he brings an array of clinical resources to his research, including stem cells and live imaging data. Second, he and his students are recognized authorities in a broad array of state-of-the-art technologies. Most recently, he was invited as a Moderator for the Gene Editing/Rewriting the Genome session during the 65th American Society of Human Genetics Annual Meeting.
- Table of contents (9 chapters)
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Viral Vectors, Engineered Cells and the CRISPR Revolution
Pages 3-27
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Combining Engineered Nucleases with Adeno-associated Viral Vectors for Therapeutic Gene Editing
Pages 29-42
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From Reductionism to Holism: Toward a More Complete View of Development Through Genome Engineering
Pages 45-74
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A Transgenic Core Facility’s Experience in Genome Editing Revolution
Pages 75-90
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Genome Editing to Study Ca2+ Homeostasis in Zebrafish Cone Photoreceptors
Pages 91-100
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Table of contents (9 chapters)
- Download Sample pages 1 PDF (288 KB)
- Download Table of contents PDF (668.9 KB)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Precision Medicine, CRISPR, and Genome Engineering
- Book Subtitle
- Moving from Association to Biology and Therapeutics
- Editors
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- Stephen H. Tsang
- Series Title
- Advances in Experimental Medicine and Biology
- Series Volume
- 1016
- Copyright
- 2017
- Publisher
- Springer International Publishing
- Copyright Holder
- Springer International Publishing AG
- eBook ISBN
- 978-3-319-63904-8
- DOI
- 10.1007/978-3-319-63904-8
- Hardcover ISBN
- 978-3-319-63903-1
- Softcover ISBN
- 978-3-319-87667-2
- Series ISSN
- 0065-2598
- Edition Number
- 1
- Number of Pages
- IX, 178
- Number of Illustrations
- 4 b/w illustrations, 15 illustrations in colour
- Topics
