Biology of Extracellular Matrix

Extracellular Matrix in Tumor Biology

Editors: Brekken, Rolf A., Stupack, Dwayne (Eds.)

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  • Gives an overview on influence of Extracellular Matrix on tumor progression
  • Highlights modelling approaches leading to a better understanding of disease mechanisms
  • A useful source of information for researchers and medical doctors alike
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eBook $129.00
price for USA in USD (gross)
  • ISBN 978-3-319-60907-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-3-319-60906-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA in USD
  • ISBN 978-3-319-86956-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression.  The book addresses researchers working on cancer biology or ECM, and oncologists alike.

About the authors

​Rolf Brekken is Professor of Surgery and Pharmacology and Deputy Director of the Hamon Center Therapeutic Oncology Research at UT Southwestern. Dr. Brekken’s laboratory studies ECM signaling in tumors, therapeutic immune reactivation and how immune cells contribute to the metastatic cascade. He has authored over 150 peer-reviewed publications and is currently a senior editor at Cancer Research. 

Dwayne Stupack is an associate professor of Reproductive Medicine and Pathology at the University of California San Diego, Moore’s Cancer Center.  Dr. Stupack’s laboratory work has been focused on the intersection of extracellular matrix signaling, the presentation of different forms of the same matrix to cells, and cell survival during tumor metastasis.  A past councilor of the American Society for Matrix Biology with more than 90 publications, Dr. Stupack currently edits the Society’s Matrix Letter.

Table of contents (6 chapters)

Table of contents (6 chapters)
  • The Extracellular Matrix of Tumors: A Focus on Fibronectin and Fibulin-5

    Topalovski, Mary (et al.)

    Pages 1-15

  • Internalization of Collagen: An Important Matrix Turnover Pathway in Cancer

    Kuczek, Dorota Ewa (et al.)

    Pages 17-38

  • Lumican, a Small Leucine-Rich Proteoglycan, and Its Biological Function in Tumor Progression

    Pratt, Michael (et al.)

    Pages 39-49

  • Versican: Role in Cancer Tumorigenesis

    Keire, Paul A. (et al.)

    Pages 51-74

  • Engineering Advanced Models of the Glioblastoma Microenvironment Using Biomaterials

    Rape, Andrew (et al.)

    Pages 75-89

Buy this book

eBook $129.00
price for USA in USD (gross)
  • ISBN 978-3-319-60907-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-3-319-60906-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA in USD
  • ISBN 978-3-319-86956-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Extracellular Matrix in Tumor Biology
Editors
  • Rolf A. Brekken
  • Dwayne Stupack
Series Title
Biology of Extracellular Matrix
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-60907-2
DOI
10.1007/978-3-319-60907-2
Hardcover ISBN
978-3-319-60906-5
Softcover ISBN
978-3-319-86956-8
Series ISSN
0887-3224
Edition Number
1
Number of Pages
IX, 115
Number of Illustrations
1 b/w illustrations, 22 illustrations in colour
Topics