Cancer Drug Discovery and Development

Tumor Organoids

Editors: Soker, Shay, Skardal, Aleksander (Eds.)

  • Highlights the development by the emerging field of regenerative medicine of bioengineered tissue platforms that best mimic the structure and cellular heterogeneity of in vivo tissue
  • Details how microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue--resulting in viability for longer periods of time
  • Explores the potential of bioengineering and microengineering to aid in overcoming limitations to genetic and histological tumor classification and the development of personalized therapies
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eBook 130,89 €
price for Spain (gross)
  • ISBN 978-3-319-60511-1
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  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 166,39 €
price for Spain (gross)
  • ISBN 978-3-319-60509-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

About the authors

Shay Soker, PhD, is Professor, Regenerative Medicine, Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine.
Aleksander Skardal, PhD, is Assistant Professor, Regenerative Medicine and Biomedical Engineering, Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine.

Table of contents (10 chapters)

  • Techniques to Produce and Culture Lung Tumor Organoids

    Yamanishi, Cameron (et al.)

    Pages 1-15

    Preview Buy Chapter 30,19 €
  • Tissue Organoids: Liver

    Solanas, Estela (et al.)

    Pages 17-33

  • Mammary Gland Organoids

    Sampayo, Rocío, PhD (et al.)

    Pages 35-49

  • Biofabrication Technologies for Developing In Vitro Tumor Models

    Mazzocchi, Andrea (et al.)

    Pages 51-70

  • Three Dimensional In Vitro Tumor Platforms for Cancer Discovery

    Gadde, Manasa (et al.)

    Pages 71-94

Buy this book

eBook 130,89 €
price for Spain (gross)
  • ISBN 978-3-319-60511-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 166,39 €
price for Spain (gross)
  • ISBN 978-3-319-60509-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Tumor Organoids
Editors
  • Shay Soker
  • Aleksander Skardal
Series Title
Cancer Drug Discovery and Development
Copyright
2018
Publisher
Humana Press
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-60511-1
DOI
10.1007/978-3-319-60511-1
Hardcover ISBN
978-3-319-60509-8
Series ISSN
2196-9906
Edition Number
1
Number of Pages
XVI, 213
Number of Illustrations and Tables
2 b/w illustrations, 50 illustrations in colour
Topics