The Structural Basis of Arrestin Functions

Editors: Gurevich, Vsevolod V. (Ed.)

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  • Gives a unique insight of the connection between protein structure and function of arrestin and its broad implications
  • Discussed are structure-based redesign of signalling proteins paves the way for novel approaches to gene therapy
  • Presents a unified view of the structural basis of the various branches of arrestin-mediated signalling
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  • ISBN 978-3-319-57553-7
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  • ISBN 978-3-319-86191-3
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About this book

This volume summarizes our current understanding of the structural basis of the functions of arrestin family of proteins. Arrestins were first discovered as key players in the desensitization of G protein-coupled receptors (GPCRs). Recent studies showed that arrestins are important signal transducers in their own right, organizing multi-protein complexes and scaffolding numerous signaling cascades that regulate cell proliferation, differentiation, and apoptotic death.

Here arrestin functions are described primarily from the structural prospective. The book covers basal structure of arrestin proteins, receptor binding-induced conformational changes in arrestins, as well as the structure of “pre-activated” mutants. Particular focus is on the arrestin elements interacting with numerous binding partners, GPCRs and cytoplasmic signaling proteins. We expect that this information and insights will help to understand and exploit the phenomenon of signaling bias, which is a new promising direction in drug discovery.
The chapters are written by the world-class specialists in the field, mostly the people who actually contributed the data discussed. The book gives coherent historical prospective and describes the most recent findings.
The book would be particularly useful for scientists in academia and industry working in the fields of pharmacology, cell biology, structural biology, and drug discovery. We expect that the focus on the molecular basis of protein-protein interactions would help to develop novel tools for engaging this important type of targets for research and therapeutic purposes.


About the authors

Dr. Gurevich got his PhD in Bioorganic Chemistry at the Shemyakin Institute in Moscow. He studied structure and function of arrestin proteins since he joined the lab of Dr. Benovic as a post-doc in 1991. Dr. Gurevich’s studies revealed why arrestins prefer active phosphorylated GPCRs and how they sense receptor-attached phosphates. His lab constructed phosphorylation-independent arrestin mutants and tested their ability to compensate for the defects of GPCR phosphorylation. His lab elucidated the structural basis of arrestin preference for particular GPCRs and constructed the first non-visual arrestins with high receptor specificity. In collaboration with different crystallographers Dr. Gurevich’s lab solved the structures of all four vertebrate arrestins in basal conformation and the structure of the arrestin-rhodopsin complex.

Table of contents (19 chapters)

Table of contents (19 chapters)
  • Arrestins: Discovery of the Family and Functional Role of Conformational Flexibility

    Gurevich, Vsevolod V. (et al.)

    Pages 3-18

  • Overview of Arrestin Mediated Signaling with Receptors and Non-receptor Binding Partners

    Zhuo, Ya (et al.)

    Pages 19-29

  • Initial Crystallographic Studies of Visual Arrestin: Insights and Perspectives

    Hirsch, Joel A.

    Pages 33-42

  • Structural Basis for β-Arrestins in GPCR Trafficking

    Yoo, Sungsoo M. (et al.)

    Pages 43-57

  • Arrestin-3: The Structural Basis of Lower Receptor Selectivity

    Spiller, Benjamin W. (et al.)

    Pages 59-67

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-3-319-57553-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-3-319-57552-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.99
price for USA in USD
  • ISBN 978-3-319-86191-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
The Structural Basis of Arrestin Functions
Editors
  • Vsevolod V. Gurevich
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-57553-7
DOI
10.1007/978-3-319-57553-7
Hardcover ISBN
978-3-319-57552-0
Softcover ISBN
978-3-319-86191-3
Edition Number
1
Number of Pages
IX, 304
Number of Illustrations
2 b/w illustrations, 51 illustrations in colour
Topics