Oxygen Transport to Tissue XXXIX

1. Front Matter

   Pages i-xxx

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2. Cell Metabolism, Tissue Oxygenation and Treatment

   1. Front Matter

      Pages 1-1

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   2. Oxygen Sensing by the Carotid Body: Past and Present

      • Nanduri R. Prabhakar, Ying-Jie Peng

      Pages 3-8

   3. Predicted Decrease in Membrane Oxygen Permeability with Addition of Cholesterol

      • Gary Angles, Rachel Dotson, Kristina Bueche, Sally C. Pias

      Pages 9-14

   4. Chronic Diseases as Barriers to Oxygen Delivery: A Unifying Hypothesis of Tissue Reoxygenation Therapy

      • G. A. Perdrizet

      Pages 15-20

   5. Dorsiflexor Muscle Oxygenation During Low, Moderate and Submaximal Sustained Isometric Contraction

      • Adkham Paiziev, Martin Wolf, Fikrat Kerimov

      Pages 21-26

   6. Factors Determining the Oxygen Permeability of Biological Membranes: Oxygen Transport Across Eye Lens Fiber-Cell Plasma Membranes

      • Witold Karol Subczynski, Justyna Widomska, Laxman Mainali

      Pages 27-34

   7. Multi-site Measurements of Muscle O2 Dynamics During Cycling Exercise in Early Post-myocardial Infarction

      • Shun Takagi, Ryotaro Kime, Norio Murase, Masatsugu Niwayama, Takuya Osada, Toshihito Katsumura

      Pages 35-41

   8. Effects of 8 Weeks’ Training on Systemic and Muscle Oxygen Dynamics in University Rugby Players

      • Shun Takagi, Ryotaro Kime, Masatsugu Niwayama, Kuniaki Hirayama, Shizuo Sakamoto

      Pages 43-49

   9. Imaging Redox State in Mouse Muscles of Different Ages

      • Lily Moon, David W. Frederick, Joseph A. Baur, Lin Z. Li

      Pages 51-57

   10. Amino Acid Hydration Decreases Radiation-Induced Nausea in Mice: A Pica Model

       • Liangjie Yin, Lauren Vaught, Paul Okunieff, Katherine Casey-Sawicki, Sadasivan Vidyasagar

       Pages 59-65

   11. Evaluation of Haemoglobin and Cytochrome Responses During Forearm Ischaemia Using Multi-wavelength Time Domain NIRS

       • Frédéric Lange, Luke Dunne, Ilias Tachtsidis

       Pages 67-72Open Access

   12. Influence of Free Radicals on the Intrinsic MRI Relaxation Properties

       • Rong-Wen Tain, Alessandro M. Scotti, Weiguo Li, Xiaohong Joe Zhou, Kejia Cai

       Pages 73-79

   13. Inter-individual Differences in Exercise-Induced Spatial Working Memory Improvement: A Near-Infrared Spectroscopy Study

       • Yudai Yamazaki, Daisuke Sato, Koya Yamashiro, Atsuhiro Tsubaki, Yui Yamaguchi, Nana Takehara et al.

       Pages 81-88

3. Cancer Oxygenation and Metabolism

   1. Front Matter

      Pages 89-89

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   2. Tumor Oxygenation Status: Facts and Fallacies

      • Peter Vaupel, Arnulf Mayer

      Pages 91-99

   3. Multiparametric Analysis of the Tumor Microenvironment: Hypoxia Markers and Beyond

      • Arnulf Mayer, Peter Vaupel

      Pages 101-107

   4. Computational Simulation of Tumor Hypoxia Based on In Vivo Microvasculature Assessed in a Dorsal Skin Window Chamber

      • Lina Xu, Peter Vaupel, Siwei Bai, Bjoern Menze, Kuangyu Shi

      Pages 109-117

   5. Hypoxia-Related Tumor Acidosis Affects MicroRNA Expression Pattern in Prostate and Breast Tumor Cells

      • A. Riemann, S. Reime, O. Thews

      Pages 119-124

4. Brain Oxygenation and Function

   1. Front Matter

      Pages 125-125

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This volume presents all aspects of delivery of oxygen to tissues and tumors in peer reviewed short articles.  Both overview and the most recent, advanced techniques for oxygen measurement are presented.   Articles and peer reviewers include those from leaders in their field.  Topics such as molecular signaling in the organismal and tumor response to low levels of local oxygenation, hypoxia inducible factor (HIF) , cancer metabolism, individual human and animal response to oxygen changes monitored by optical/near infrared spectroscopy/ tomography to novel electron resonance spectroscopy and spectroscopic imaging, instrumentation, progress in blood substitute research, retinal physiology, cellular hypoxia, mitochondrial function; brain oxygenation and function;  oxygen transport in sports, hypoxia in diseases and clinical care.

Chapters 10 and 19 of this book are open access under a CC BY 4.0 license.

• Molecular oxygen
• Oxygen metabolism
• Oxygen transport
• Perfusion
• Blood substitutes
• Tumor hypoxia
• Hypoxia
• Cerebral oxygenation
• Sports medicine
• Oxygen measurement
• Oxygen imaging
• Electron paramagnetic resonance
• Electron paramagnetic resonance oxygen imaging
• Metabolic imaging
• Hypoxia signaling
• Retinal oxygenation

• Department of Radiation and Cellular Oncology, Center for EPR Imaging In Vivo Physiology, University of Chicago, Chicago, USA

  Howard J. Halpern, Boris Epel

• Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, USA

  Joseph C. LaManna

• Microvascular Measurements, St. Lorenzen, Italy

  David K. Harrison

Howard J. Halpern  is Professor of Radiation and Cellular Oncology at the University of Chicago and Director, NIH Center for Electron Paramagnetic Resonance (EPR) Imaging In Vivo Physiology.  Dr. Halpern is both a physicist, supporting a graduate student as a member of the Committee of Medical Physics and a physician training Radiation Oncology residents.  His principle research focus is the application of EPR imaging for near absolute pO2 image formation.

Joseph C. LaManna is the Jeanette M. and Joseph S. Silber Professor of Brain Sciences at the Case Western Reserve University School of Medicine, Department of Physiology & Biophysics. He is the former chair of the Department of Anatomy at CWRU.  He is a Past President of The Federation of American Societies for Experimental Biology (FASEB), and Secretary of the International Society for Cerebral Blood Blow and Metabolism. He has published over 250 papers on the topic of oxygen and energymetabolism, especially in the field of brain blood flow and metabolism. He has been a member of the International Society for Oxygen Transport to Tissue since 1976, serving as President of the ISOTT in 2009. In 2016 he became the editor in Chief of the ISOTT proceedings.

David Harrison is CEO of Microvascular Measurements and acts as honorary Senior Scientific Consultant for Oroboros Instruments (Innsbruck, Austria). In this capacity he has recently been responsible for the development of lightguide spectrophotometry for the continuous measurement of cytochrome redox state in mitochondria during high resolution respirometry. Prior to this, he was Head of the Durham Unit of the Regional Medical Physics Department and Honorary Senior Lecturer in Medical Physics, Institute of Cellular Medicine, Newcastle University, UK until retiring from the NHS in 2009. He is author or co-author of over 130 publications, mainly in the field of blood flow and oxygen transport to tissue. He has been a member of ISOTT for over 30 years including being President in 1996. Since 2004 he has been Scientific Editor of the “Oxygen Transport to Tissue” volumes.

 Boris Epel was awarded his Ph.D. in physics in Kazan Federal University, Russia in 1999. He did his post-doctoral training in Weizmann Institute of Science, Israel and in the Max-Plank Institute for Bioinorganic Chemistry. Currently Boris Epel is a Research Professor in the Department of Radiation and Cellular Oncology and scientific manager of the Center for EPR imaging in vivo Physiology. The major focus of research is application of in vivo oxygen imaging to the improved radiation treatment of cancer. Boris Epel has been a member of the International Society for Oxygen Transport to Tissue since 2015.​

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