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Molecular Oncology: Underlying Mechanisms and Translational Advancements

  • Book
  • © 2017

Overview

Editors:
  1. Ammad Ahmad Farooqi

    1. Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Muhammad Ismail

    1. Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer.

  • This book will present molecular basis of cancer development, progression and development of resistance against wide ranging therapeutics information

  • Book is appropriately designed for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments

  • Useful for training graduate medical students

  • Includes supplementary material: sn.pub/extras

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Legacy of Vitamin D: Role of Vitamin D in Prevention of Gynecological Cancers

    • Rukset Attar, Maria Luisa Gasparri, Talha Abdul Halim, Dana Al Hamwi, Ilknur Ucak, Sundas Fayyaz et al.
    Pages 1-14

  3. Microtubule Targeting Agents in Cancer Therapy: Elucidating the Underlying Molecular Mechanisms

    • Mohadeseh Hasanpourghadi, Ashok Kumar Pandurangan, Mohd. Rais Mustafa
    Pages 15-65

  4. New Challenges in Cancer Therapy: MAPK Inhibitors from Bench to Bedside

    • Catherine Ropert, Hugo W. Huth
    Pages 67-91

  5. Adenosine Signaling Pathways as Potential Therapeutic Targets in Prostate Cancer Disease

    • Silvia Novío, María Jesús Núñez-Iglesias, Manuel Freire-Garabal
    Pages 93-107

  6. Emerging Role of ncRNAs in Cancer Biology: Techniques for Diagnostic Monitoring and Potential ncRNA-Based Therapies

    • Palmiro Poltronieri, Oscar F. D’Urso, Massimo Mallardo
    Pages 109-128

  7. Exosomes: New Biomarkers for Targeted Cancer Therapy

    • Chiara Martinelli
    Pages 129-157

  8. Targeting of EGFR Induced Signaling Network in Hepatocellular Carcinoma

    • Aliye Aras Perk, Riffat Batool, Sobia Kanwal, Edyta Pawlak-Adamska, Oskar Nowak, Muhammad Sheeraz Ahmad et al.
    Pages 159-171

  9. Targeting of Heat Shock Proteins by Natural Products in Cancer

    • Evren Önay Uçar, Murat Pekmez, Nazlı Arda
    Pages 173-192

  10. The Immunobiology of Cancer: From Tumor Escape to Cancer Immunoediting Towards Immunotherapy in Gynecologic Oncology

    • Maria Luisa Gasparri, Ilary Ruscito, Katayoun Taghavi, Ammad Ahmad Farooqi, Andrea Papadia, Chiara Focaccetti et al.
    Pages 193-204

  11. Investigation of Androgen Receptor Signaling Pathways with Epigenetic Machinery in Prostate Cancer

    • Ken-ichi Takayama, Satoshi Inoue
    Pages 205-222

  12. Adenoid Cystic Carcinoma of the Lacrimal Gland: Clinical, Genetic and Molecular Characteristics

    • Steven Pappas, Ke Jin, Brian C. Tse, David T. Tse, Daniel Pelaez, Wensi Tao
    Pages 223-236

  13. Role of TRAIL and miR-34a as Therapeutic Agents in Prostate Cancer: Increasing the Armory of Micro-Musketeers

    • Agnieszka Sobczak-Kupiec, Muhammad Javed Iqbal, Muhammad Zahid Qureshi, Qaisar Mansoor, Seyed Mohammad Nabavi, Jelena Purenovic et al.
    Pages 237-245

  14. Components from the Traditional Chinese Medicine Acts as Protein Kinase Inhibitors

    • Minghua Liu, Ge Zhao, Shousong Cao, Yangyang Zhang, Xiaofang Li, Xiukun Lin
    Pages 247-272

  15. Impact and Application of Nutraceuticals on Inflammation-Induced Colorectal Cancer Development

    • Yi Liu
    Pages 273-291

  16. Back Matter

    Pages 293-300
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Keywords

About this book

Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity, dysregulation of spatio-temporally controlled signaling cascades, and loss of apoptosis are contributory in cancer development, progression and the development of resistance against different therapeutics. It is becoming progressively more understandable that earlier detection of pre-existing or emerging resistance against different therapeutics may prove to be helpful in personalizing the use of targeted cancer therapy. 


Despite the fact that there is a continuously increasing list of books, being guest edited by researchers, books on the subject are often composed of invited reviews without proper sequence and continuity and designed for a particular readership. This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer.


Editors and Affiliations

  • Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan

    Ammad Ahmad Farooqi, Muhammad Ismail

About the editors

Ammad Ahmad Farooqi is currently a Senior Scientist at the Institute of Biomedical and Genetic Engineering (IBGE), in Islamabad, Pakistan. His area of research is tightly focused on cancer genetics and therapeutics.

Professor Muhammad Ismail has a Ph.D. in Biotechnology and is currently the Director of the Institute of Biomedical and Genetic Engineering (IBGE), in Islamabad. His main focus of research is Cancer Genetics and Therapeutics, Nanomedicine and Pharmacogenomics.




Bibliographic Information

  • Book Title: Molecular Oncology: Underlying Mechanisms and Translational Advancements

  • Editors: Ammad Ahmad Farooqi, Muhammad Ismail

  • DOI: https://doi.org/10.1007/978-3-319-53082-6

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-53081-9Published: 05 April 2017

  • Softcover ISBN: 978-3-319-85057-3Published: 21 July 2018

  • eBook ISBN: 978-3-319-53082-6Published: 29 March 2017

  • Edition Number: 1

  • Number of Pages: X, 302

  • Number of Illustrations: 3 b/w illustrations, 24 illustrations in colour

  • Topics: Cancer Research, Oncology

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