MIF Family Cytokines in Innate Immunity and Homeostasis

1. Front Matter

   Pages i-viii

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2. MIF- and CD74-Dependent Mechanisms

   • Shirly Becker-Herman, Naama Gil, Lihi Radomir, Idit Shachar

   Pages 1-20

3. HSP90-Stabilized MIF in Oncogenesis and Cell Growth Control

   • Ramona Schulz-Heddergott, Ute M. Moll

   Pages 21-42

4. CD74, MIF and Breast Tumorigenesis: Insights from Recent Large-Scale Tumour Genomics and Proteomics Studies

   • Metodi V. Metodiev

   Pages 43-57

5. MIF-Dependent Regulation of Monocyte/Macrophage Polarization

   • Kavitha Yaddanapudi, Robert A. Mitchell

   Pages 59-76

6. Advances in Understanding the Role of MIF in the Pathogenesis of Autoimmune Diseases

   • Saisha A. Nalawade, Yousef Al-Abed, Thomas G. Forsthuber

   Pages 77-95

7. Role of MIF in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

   • Gil Benedek, Roberto Meza-Romero, Arthur A. Vandenbark

   Pages 97-107

8. Role of MIF in Hepatic Inflammatory Diseases and Fibrosis

   • Veronica Marin, Gemma Odena, Kyle Poulsen, Claudio Tiribelli, Stefano Bellentani, Andrea Barchetti et al.

   Pages 109-134

9. MIF and Pulmonary Disease

   • Timothy Baker, Patty J. Lee, Maor Sauler

   Pages 135-144

10. MIF Mediates Pelvic Inflammation and Pain

    • Fei Ma, Katherine L. Meyer-Siegler, Karin N. Westlund, Pedro L. Vera

    Pages 145-155

11. MIF Family Proteins in Cardiac Ischemia/Reperfusion Injury

    • Christian Stoppe, Jürgen Bernhagen

    Pages 157-174

12. The MIF-CD74 Inflammatory Axis in Alphaviral Infection

    • Lara J. Herrero, Ali Zaid, Margit Mutso, Suresh Mahalingam

    Pages 175-187

13. MIF in Eosinophilic Inflammation

    • Marcelo T. Bozza, Claudia N. Paiva, Priscilla C. Olsen

    Pages 189-202

14. The Role of MIF in Parasitic Infections

    • Cesar Terrazas, James C. Stock, Jeniffer Kimble, Ellen Moretti, Sanjay Varikuti, Abhay R. Satoskar

    Pages 203-219

15. Parasite MIF Orthologs

    • Thomas Holowka, Richard Bucala

    Pages 221-239

16. Back Matter

    Pages 241-246

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The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses.  MIF’s molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized.  MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.

• Infectious Diseases
• MIF Biology
• MIF-directed therapies
• MMIF
• Macrophage Migration Inhibitory Factor (MIF)
• Parasite MIF Orthologs

• The Anlyan Center, Yale School of Medicine, Yale University, New Haven, USA

  Richard Bucala

• Department of Vascular Biology, Institute for Stroke and Dementia Research, Ludwig-Maximilians-University (LMU), Munich, Germany

  Jürgen Bernhagen

Richard Bucala, MD PhD; Professor of Medicine, Pathology, and Epidemiology & Public Health at Yale University, School of Medicine, New Haven, CT, USA Jürgen Bernhagen, PhD; Institute of Biochemistry and Molecular Cell Biology, Universitätsklinikum Aachen, RWTH Aachen, Germany

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