Springer Theses

Chromatin Architecture

Advances From High-resolution Single Molecule DNA Imaging

Authors: Prakash, Kirti

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  • Nominated as an outstanding PhD thesis by the Institute of Molecular Biology, Mainz, and Heidelberg University, Germany 
  • Provides a pictorial description of super-resolution microscopy and chromatin architecture with 100 color photographs
  • Presents a comprehensive overview of chromatin research, from the early work on chromosomes to the latest genomics and microscopy techniques
  •  Offers new insights into the way the genome is organized, in light of recent exciting data from super-resolution microscopy
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eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-319-52183-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-319-52182-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.99
price for USA in USD
  • ISBN 978-3-319-84841-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book sheds new light on the current state of knowledge concerning chromatin organization. Particular emphasis is given to the new imaging potential offered by super-resolution microscopy, which allows DNA imaging with a very high labeling density.

From the early work on chromosomes by Walther Flemming in the nineteenth century to recent advances in genomics, the history of chromatin research now spans more than a century. The various milestones, such as the discovery of the double helix structure, the sequencing of the human genome, and the recent description of the genome in 3D space, show that understanding chromatin and chromosome function requires a clear understanding of its structure.

Presenting cutting-edge data from super-resolution single molecule microscopy, the book demonstrates that chromatin manifests several levels of folding, from nucleosomes to chromosomes. Chromatin domains emerge as a new fundamental building block of chromatin architecture, with functions possibly related to gene regulation.

A detailed description of chromatin folding in the pachytene stage of meiosis serves as a model for exploring this functionality, showing the apparent interplay between structure, function, and epigenetic regulation. Lastly, the book discusses possible new avenues of innovation to describe chromatin’s organization and functions.

Gathering essential insights on chromatin architecture, the book offers students an introduction to microscopy and its application to chromatin organization, while also providing advanced readers with new ideas for future research.

About the authors

Kirti Prakash holds a Ph.D. in Biology from Heidelberg University, Germany and a Masters degree in Computer Science and Engineering from Aalto University, Finland. Both an expert in computational biology and microscopy, he has studied various aspects of chromatin organization and epigenetics using superresolution microscopy and genomic approaches. Currently, he is working on a systematic characterization of chromatin architecture, from nucleosome to chromosome level.

Table of contents (5 chapters)

Table of contents (5 chapters)

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-3-319-52183-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-319-52182-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $159.99
price for USA in USD
  • ISBN 978-3-319-84841-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Chromatin Architecture
Book Subtitle
Advances From High-resolution Single Molecule DNA Imaging
Authors
Series Title
Springer Theses
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-52183-1
DOI
10.1007/978-3-319-52183-1
Hardcover ISBN
978-3-319-52182-4
Softcover ISBN
978-3-319-84841-9
Series ISSN
2190-5053
Edition Number
1
Number of Pages
LIII, 152
Number of Illustrations
51 b/w illustrations, 50 illustrations in colour
Topics