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Cancer Drug Discovery and Development

Liquid Biopsies in Solid Tumors

Editors: Cristofanilli, Massimo (Ed.)

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  • Liquid biopsy is a new and exciting diagnostic field in breast cancer
  •           Novel technologies allows for a real-time, minimally invasive, longitudinal assessment of molecular characteristics of the disease          Liquid biopsy can be used as tool to assess efficacy in advanced breast cancer and can be used for the molecular detection of minimally residual disease           Understanding the technical aspects, clinical and diagnostic applications for liquid biopsy is critical for medical oncologist that want to advance precision medicine
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About this book

This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype.

Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) opened to the option of a comprehensive blood-based tumor analysis. Similar information can be obtained by analysis of exosome, a natural packaging and messaging system being explored in advanced malignancies. The final frontier is the evaluation of immune cells determinant of innate and adaptive immunity.




About the authors

Massimo Crisofanilli, MD, F.A.C.P, is Professor of Medical Oncology, Department of Medical Oncology, Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA.

Reviews

“The book 'Liquid biopsies in solid tumours' provides an overview of currently available technological approaches and clinical applications of liquid biopsies that offer an attractive alternative to invasive tumour biopsies. … This book collects contribution from experts in the field of blood-based diagnostics. They help us to understand the future of early cancer detection, characterization and monitoring via liquid biopsies strategies, providing clinicians with the advantage to understand, predict and intervene.” ( Bozena Smolkova, Neoplasma, Vol. 65 (1), January, 2018)

Table of contents (8 chapters)

Table of contents (8 chapters)
  • Blood-Based Diagnostics in Solid Tumors: An Overview

    Pages 1-13

    Toss, Angela (et al.)

  • Circulating Tumour Cells in Primary Disease: The Seed for Metastasis

    Pages 15-40

    Pondé, Noam Falbel (et al.)

  • Enumeration and Molecular Analysis of CTCs in Metastatic Disease: The Breast Cancer Model

    Pages 41-65

    Parisi, Cleo (et al.)

  • Epithelial-Mesenchymal Transition (EMT) and Cancer Stem Cells (CSCs): The Traveling Metastasis

    Pages 67-80

    Mego, Michal (et al.)

  • Detecting and Monitoring Circulating Stromal Cells from Solid Tumors Using Blood-Based Biopsies in the Twenty-First Century: Have Circulating Stromal Cells Come of Age?

    Pages 81-104

    Adams, Daniel L. (et al.)

Buy this book

eBook $139.00
price for USA in USD
  • ISBN 978-3-319-50956-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-319-50955-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-3-319-84530-2
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Liquid Biopsies in Solid Tumors
Editors
  • Massimo Cristofanilli
Series Title
Cancer Drug Discovery and Development
Copyright
2017
Publisher
Humana Press
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-50956-3
DOI
10.1007/978-3-319-50956-3
Hardcover ISBN
978-3-319-50955-6
Softcover ISBN
978-3-319-84530-2
Series ISSN
2196-9906
Edition Number
1
Number of Pages
X, 161
Number of Illustrations
2 b/w illustrations, 12 illustrations in colour
Topics

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