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Liquid Biopsies in Solid Tumors

  • Book
  • © 2017

Overview

Editors:
  1. Massimo Cristofanilli

    1. Department of Medicine-Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, USA

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  • Liquid biopsy is a new and exciting diagnostic field in breast cancer
  • Novel technologies allows for a real-time, minimally invasive, longitudinal assessment of molecular characteristics of the disease
  • Liquid biopsy can be used as tool to assess efficacy in advanced breast cancer and can be used for the molecular detection of minimally residual disease
  • Understanding the technical aspects, clinical and diagnostic applications for liquid biopsy is critical for medical oncologist that want to advance precision medicine
  • Includes supplementary material: sn.pub/extras

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-x
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  2. Blood-Based Diagnostics in Solid Tumors: An Overview

    • Angela Toss, Massimo Cristofanilli
    Pages 1-13

  3. Circulating Tumour Cells in Primary Disease: The Seed for Metastasis

    • Noam Falbel Pondé, Michail Ignatiadis
    Pages 15-40

  4. Enumeration and Molecular Analysis of CTCs in Metastatic Disease: The Breast Cancer Model

    • Cleo Parisi, Evi Lianidou
    Pages 41-65

  5. Epithelial-Mesenchymal Transition (EMT) and Cancer Stem Cells (CSCs): The Traveling Metastasis

    • Michal Mego, James Reuben, Sendurai A. Mani
    Pages 67-80

  6. Detecting and Monitoring Circulating Stromal Cells from Solid Tumors Using Blood-Based Biopsies in the Twenty-First Century: Have Circulating Stromal Cells Come of Age?

    • Daniel L. Adams, Massimo Cristofanilli
    Pages 81-104

  7. Circulating Free Tumor DNA (ctDNA): The Real-Time Liquid Biopsy

    • Kelly Kyker-Snowman, Ben Ho Park
    Pages 105-118

  8. CTCs and ctDNA: Two Tales of a Complex Biology

    • Paul W. Dempsey
    Pages 119-137

  9. Exosomes: The Next Small Thing

    • Vincent J. O’Neill
    Pages 139-155

  10. Back Matter

    Pages 157-161
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Keywords

About this book

This volume, with chapters written by experts in the field of cancerous tumors, details the key factors associated with liquid biopsies in solid tumors: blood-based diagnostics; circulating tumor cells; enumeration and molecular analysis (association with breast cancer); epithelialmesenchymal transition; detection and monitoring; circulating-free tumor DNA; CTCs and ctDNA; and the exosome. The field of blood-based diagnostics is rapidly evolving demonstrating the possibility of real-time molecular analysis of cancer cells and their phenotype and genotype.

Circulating Tumor Cell (CTCs) have demonstrated prognostic and predictive value in advanced cancer and represents a source of tumor cells for transcriptome and genomic analysis. Most recently, the detection of genomic abnormalities in the peripheral blood by sensitive and selective PCR methods (liquid biopsy) opened to the option of a comprehensive blood-based tumor analysis. Similar information can be obtained by analysis of exosome, a natural packaging and messaging system being explored in advanced malignancies. The final frontier is the evaluation of immune cells determinant of innate and adaptive immunity.




Reviews

“The book 'Liquid biopsies in solid tumours' provides an overview of currently available technological approaches and clinical applications of liquid biopsies that offer an attractive alternative to invasive tumour biopsies. … This book collects contribution from experts in the field of blood-based diagnostics. They help us to understand the future of early cancer detection, characterization and monitoring via liquid biopsies strategies, providing clinicians with the advantage to understand, predict and intervene.” ( Bozena Smolkova, Neoplasma, Vol. 65 (1), January, 2018)

Editors and Affiliations

  • Department of Medicine-Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, USA

    Massimo Cristofanilli

About the editor

Massimo Crisofanilli, MD, F.A.C.P, is Professor of Medical Oncology, Department of Medical Oncology, Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA.

Bibliographic Information

  • Book Title: Liquid Biopsies in Solid Tumors

  • Editors: Massimo Cristofanilli

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-3-319-50956-3

  • Publisher: Humana Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-50955-6Published: 03 April 2017

  • Softcover ISBN: 978-3-319-84530-2Published: 08 May 2018

  • eBook ISBN: 978-3-319-50956-3Published: 25 March 2017

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: X, 161

  • Number of Illustrations: 2 b/w illustrations, 12 illustrations in colour

  • Topics: Cancer Research

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