Advances in Experimental Medicine and Biology

Sigma Receptors: Their Role in Disease and as Therapeutic Targets

Editors: Smith, Sylvia B., Su, Tsung-Ping (Eds.)

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  • Very few books about Sigma receptors, yet the field regarding Sigma receptors has exploded
  • A comprehensive treatise on this unique protein
  • Of significant relevance to very severe diseases (blindness, ALS, AD, PK, pain, schizophrenia, HD)
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eBook $169.00
price for USA in USD (gross)
  • ISBN 978-3-319-50174-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-3-319-50172-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-3-319-84335-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types.  It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors.  Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.

Table of contents (20 chapters)

Table of contents (20 chapters)
  • Introduction to Sigma Receptors: Their Role in Disease and as Therapeutic Targets

    Pages 1-4

    Smith, Sylvia B.

  • Structural Perspectives on Sigma-1 Receptor Function

    Pages 5-13

    Alon, Assaf (et al.)

  • A Review of the Human Sigma-1 Receptor Structure

    Pages 15-29

    Ossa, Felipe (et al.)

  • Fluorinated PET Tracers for Molecular Imaging of σ1 Receptors in the Central Nervous System

    Pages 31-48

    Weber, Frauke (et al.)

  • The Evolution of the Sigma-2 (σ2) Receptor from Obscure Binding Site to Bona Fide Therapeutic Target

    Pages 49-61

    Zeng, Chenbo (et al.)

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-3-319-50174-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-3-319-50172-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-3-319-84335-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Sigma Receptors: Their Role in Disease and as Therapeutic Targets
Editors
  • Sylvia B. Smith
  • Tsung-Ping Su
Series Title
Advances in Experimental Medicine and Biology
Series Volume
964
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG (outside the USA)
eBook ISBN
978-3-319-50174-1
DOI
10.1007/978-3-319-50174-1
Hardcover ISBN
978-3-319-50172-7
Softcover ISBN
978-3-319-84335-3
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIII, 312
Number of Illustrations
14 b/w illustrations, 45 illustrations in colour
Topics