AAPS Advances in the Pharmaceutical Sciences Series

Translating Molecules into Medicines

Cross-Functional Integration at the Drug Discovery-Development Interface

Editors: Bhattachar, S.N., Morrison, J., Mudra, D.R., Bender, D.M. (Eds.)

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  • First of its kind to integrate precision medicine, biopharmaceutics, and translational approaches
    Industry performance sets the stage and highlights the need for greater discovery/development integration to improve the efficiency and success rate of bring new medicines to patients
    Describes how the discovery and developmental environments can learn from each other and leverage each other’s strengths

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  • ISBN 978-3-319-50042-3
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Hardcover $219.99
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Softcover $159.99
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About this book

Tackling translational medicine with a focus on the drug discovery development-interface, this book integrates approaches and tactics from multiple disciplines, rather than just the pharmaceutical aspect of the field. The authors of each chapter address the paradox between the molecular understanding of diseases, drug discovery, and drug development. Laying out the detailed trends from various fields, different chapters are dedicated to target engagement, toxicological safety assessments, and the compelling relationship of optimizing early clinical studies with design strategies. The book also highlights the importance of balancing the three pillars: sufficient efficacy, acceptable safety and appropriate pharmacokinetics, all of which are crucial to successful efforts in discovery and development. With discussions regarding the combined approaches of molecular research, personalized medicine, pre-clinical and clinical development, as well as targeted therapies—this compendium is a flexible fit, perfect for professionals in the pharmaceutical industry and related academic fields.

About the authors

Shobha N. Bhattachar is a Director in Small Molecule Design and Development at Eli Lilly and Company. She has a Bachelor’s degree in Pharmacy from Bangalore University, India, and a Master’s degree in Pharmaceutical chemistry from the University of Kansas. Prior to joining Lilly, Bhattachar worked for eight years at Pfizer in Ann Arbor MI, in the Research Formulations group. She has authored/co-authored 15 publications covering wide ranging topics in the field of Pharmaceutical Sciences. Her current interests include the discovery-development interface, clinical candidate selection and developability assessment, clinical formulation development and biopharmaceutical aspects of drug product design.
John S. Morrison earned his doctorate in physical organic chemistry from the University of Western Ontario studying the photochemical mechanisms responsible for the light-struck reaction in beer.  After graduation John joined the Preformulation and Analytical Method Development group of Apotex Inc evaluating drug substances and novel drug product formulations.  He then transitioned to the Discovery Pharmaceutics group of Bristol-Myers Squibb characterizing early drug candidates and establishing delivery strategies for a variety of dosing routes and molecular modalities.  His current role bridges the discovery/development divide, collaboratively supporting multi-disciplinary discovery teams as well as determining and mitigating developability risks for potential clinical drug candidates.  John has also led several AAPS committees and co-organizes the ACS Drug Design and Delivery webinar series.

David M. Bender is  a Senior Research Scientist in Small Molecule Design and Development at Eli Lilly and Co.  He received a B.S in chemistry from Miami University and an M.S. in organic chemistry from Colorado State University where he conducted research into the design and synthesis of novel antibacterial agents.  He joined Eli Lilly and Co. in 1998 as a synthetic organic chemist in Discovery Chemistry Research. In 2009, he joined the Product Research and Development organization, where he has focused on formulation development, small molecule developability, absorption modeling and alternate drug delivery. Mr. Bender is currently a group leader in the Product Design and Developability group, and is responsible for overseeing the design and manufacture of clinical drug product for small molecules entering Lilly’s development pipeline. 

Daniel R. Mudra is Director of ADME at Eli Lilly and Company.  He earned his B.S. from The University of Dayton studying pharmacokinetic/pharmacodynamic effects of drug-impregnated implants and an M.S. from Loyola University Chicago investigating the biochemical regulation of the p38 kinase pathway.  He earned his doctorate in Pharmaceutical Chemistry from The University of Kansas developing in situ and computational models of absorption studying the effects of excipients on permeability, metabolism and transport.  Dr. Mudra began his industrial research career at XenoTech, LLC and has published on models of P450 induction and inhibition, drug absorption and PK.  Since joining Lilly, he has contributed to projects from target identification to clinical development across a variety of therapeutic areas.  He leads in the incorporation of mechanistic and physiologically based PK modeling including the use of molecular attributes to predict human clearance pathways. 

Table of contents (14 chapters)

Table of contents (14 chapters)
  • Pharmaceutical Industry Performance

    Pages 3-25

    Swinney, David C.

  • New Product Planning and the Drug Discovery-Development Interface

    Pages 27-38

    Reagan, Robin

  • Target Engagement Measures in Preclinical Drug Discovery: Theory, Methods, and Case Studies

    Pages 41-80

    Durham, Timothy B. (et al.)

  • In Silico ADME Techniques Used in Early-Phase Drug Discovery

    Pages 81-117

    Danielson, Matthew L. (et al.)

  • Discover Toxicology: An Early Safety Assessment Approach

    Pages 119-162

    Baker, Thomas K. (et al.)

Buy this book

eBook $119.00
price for USA in USD
  • ISBN 978-3-319-50042-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts available
Hardcover $219.99
price for USA in USD
Softcover $159.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Translating Molecules into Medicines
Book Subtitle
Cross-Functional Integration at the Drug Discovery-Development Interface
Editors
  • Shobha N. Bhattachar
  • John Morrison
  • Daniel R. Mudra
  • David M. Bender
Series Title
AAPS Advances in the Pharmaceutical Sciences Series
Series Volume
25
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
American Association of Pharmaceutical Scientists
eBook ISBN
978-3-319-50042-3
DOI
10.1007/978-3-319-50042-3
Hardcover ISBN
978-3-319-50040-9
Softcover ISBN
978-3-319-84303-2
Series ISSN
2210-7371
Edition Number
1
Number of Pages
XXIV, 461
Number of Illustrations
20 b/w illustrations, 81 illustrations in colour
Topics