Overview
- Editors:
-
-
Francisco Pelegri
-
Laboratory of Genetics, University of Wisconsin—Madison, Madison, USA
-
Michael Danilchik
-
Department of Integrative Biosciences, Oregon Health & Science University, Portland, USA
-
Ann Sutherland
-
Department of Cell Biology, University of Virginia Health System, Charlottesville, USA
- Emphasizes underlying common molecular, cellular and developmental themes between vertebrates and pro-vertebrates
- Uniquely focuses on the very earliest stages of development, at the transition between information provided by the mother in the egg and the regulation by genetic material of the embryo
- Discusses nuclear transfer, a promising new tool with applications to regenerative medicine and conservation biology?
- Includes supplementary material: sn.pub/extras
Access this book
Other ways to access
Table of contents (11 chapters)
-
-
- Zoltan Machaty, Andrew R. Miller, Lu Zhang
Pages 1-47
-
- Michael D. Sheets, Catherine A. Fox, Megan E. Dowdle, Susanne Imboden Blaser, Andy Chung, Sookhee Park
Pages 49-82
-
- Andreas Heim, Beata Rymarczyk, Thomas U. Mayer
Pages 83-116
-
- Andrew Hasley, Shawn Chavez, Michael Danilchik, Martin WĂĽhr, Francisco Pelegri
Pages 117-171
-
- Matias Escobar-Aguirre, Yaniv M. Elkouby, Mary C. Mullins
Pages 173-207
-
-
- Wei-Chia Tseng, Mumingjiang Munisha, Juan B. Gutierrez, Scott T. Dougan
Pages 307-381
-
- Tristan Aguero, Susannah Kassmer, Ramiro Alberio, Andrew Johnson, Mary Lou King
Pages 383-440
-
- Maomao Zhang, Jennifer Skirkanich, Michael A. Lampson, Peter S. Klein
Pages 441-487
-
- Petr Svoboda, Helena Fulka, Radek Malik
Pages 489-535
-
- Francisco Pelegri, Michael Danilchik, Ann Sutherland
Pages E1-E1
-
Back Matter
Pages 537-549
About this book
This book provides a comprehensive overview of topics describing the earliest steps of fertilization, from egg activation and fertilization to the activation of the zygotic genome, in various studied vertebrate model systems. The contribution of maternal and paternal factors and their role in the early embryo as parental DNA becomes modified and embryonic genes become activated is fundamental to the initiation of embryogenesis in all animal systems. It can be argued that this is a unique developmental period, when information from the parents is compressed to direct the development of the body plan of the entire organism, a process of astounding simplicity, elegance and beauty. In addition to their fundamental scientific interest, many frontiers of biomedicine, such as reproductive biology, stem cells and reprogramming, and the understanding of intergenerational diseases, depend on advances in our knowledge of these early processes. Vertebrate Development: Maternal to ZygoticControl brings together chapters from experts in various disciplines describing the latest advances related to this important developmental transition. Each chapter is a synthesis of knowledge relevant to all vertebrates, with details on specific systems as well as comparisons between the various studied vertebrate models. The editorial expertise encompasses the fields of major vertebrate model systems (mammalian, amphibian and teleost) ensuring a balanced approach to various topics. This unique book—with its combination of in-depth and up-to-date basic research, inter-species comprehensiveness and emphasis on the very early stages of animal development—is essential for research scientists studying vertebrate development, as well as being a valuable resource for college educators teaching advanced courses in developmental biology.
Editors and Affiliations
-
Laboratory of Genetics, University of Wisconsin—Madison, Madison, USA
Francisco Pelegri
-
Department of Integrative Biosciences, Oregon Health & Science University, Portland, USA
Michael Danilchik
-
Department of Cell Biology, University of Virginia Health System, Charlottesville, USA
Ann Sutherland
About the editors
Dr. Francisco Pelegri is currently a Professor in the Laboratory of Genetics at the University of Wisconsin-Madison. He received his PhD from the Massachusetts Institute of Technology and his postdoctoral position was at the Max Planck Institute for Developmental Biology, TĂĽbingen, Germany. His research focus is understanding at the cellular and molecular level processes involved in early zebrafish development, specifically but not exclusively the functional diversification of cell types.
Dr. Michael V. Danilchik is a Professor in the Department of Integrative Biosciences at Oregon Health & Science University. He received his PhD from the University of Washington and did his postdoctoral training at the University of California, Berkeley. His research interest is in cellular mechanisms of pregastrular morphogenesis, particularly cytoskeletal and membrane dynamics during cleavage-stage cytokinesis, and long-range cell-cell signaling modalities involving filopodia and extracellular vesicles.
Dr. Ann E. Sutherland is an Associate Professor, Cell Biology at the School of Medicine at University of Virginia. She earned her PhD at the University of California San Francisco. Her laboratory’s research focuses primarily on the cellular mechanisms of implantation and gastrulation in the mouse embryo and, in particular, the regulation of motility in the trophoblast cells of the implanting mouse blastocyst, and the cell behaviors leading to axial elongation in the mid-gestation embryo.