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Advances in Experimental Medicine and Biology

Vertebrate Development

Maternal to Zygotic Control

Editors: Pelegri, Francisco, Danilchik, Michael, Sutherland, Ann (Eds.)

  • Emphasizes underlying common molecular, cellular and developmental themes between vertebrates and pro-vertebrates  
  • Uniquely focuses on the very earliest stages of development, at the transition between information provided by the mother in the egg and the regulation by genetic material of the embryo  
  • Discusses nuclear transfer, a promising new tool with applications to regenerative medicine and conservation biology​
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eBook $189.00
price for USA in USD (gross)
  • ISBN 978-3-319-46095-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-319-46093-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-3-319-83439-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book provides a comprehensive overview of topics describing the earliest steps of fertilization, from egg activation and fertilization to the activation of the zygotic genome, in various studied vertebrate model systems. The contribution of maternal and paternal factors and their role in the early embryo as parental DNA becomes modified and embryonic genes become activated is fundamental to the initiation of embryogenesis in all animal systems.  It can be argued that this is a unique developmental period, when information from the parents is compressed to direct the development of the body plan of the entire organism, a process of astounding simplicity, elegance and beauty. In addition to their fundamental scientific interest, many frontiers of biomedicine, such as reproductive biology, stem cells and reprogramming, and the understanding of intergenerational diseases, depend on advances in our knowledge of these early processes. Vertebrate Development: Maternal to Zygotic Control brings together chapters from experts in various disciplines describing the latest advances related to this important developmental transition. Each chapter is a synthesis of knowledge relevant to all vertebrates, with details on specific systems as well as comparisons between the various studied vertebrate models. The editorial expertise encompasses the fields of major vertebrate model systems (mammalian, amphibian and teleost) ensuring a balanced approach to various topics. This unique book—with its combination of in-depth and up-to-date basic research, inter-species comprehensiveness and emphasis on the very early stages of animal development—is essential for research scientists studying vertebrate development, as well as being a valuable resource for college educators teaching advanced courses in developmental biology.

About the authors

Dr. Francisco Pelegri is currently a Professor in the Laboratory of Genetics at the University of Wisconsin-Madison. He received his PhD from the Massachusetts Institute of Technology and his postdoctoral position was at the Max Planck Institute for Developmental Biology, Tübingen, Germany. His research focus is understanding at the cellular and molecular level processes involved in early zebrafish development, specifically but not exclusively the functional diversification of cell types.

Dr. Michael V. Danilchik is a Professor in the Department of Integrative Biosciences at Oregon Health & Science University. He received his PhD from the University of Washington and did his postdoctoral training at the University of California, Berkeley. His research interest is in cellular mechanisms of pregastrular morphogenesis, particularly cytoskeletal and membrane dynamics during cleavage-stage cytokinesis, and long-range cell-cell signaling modalities involving filopodia and extracellular vesicles.

Dr. Ann E. Sutherland is an Associate Professor, Cell Biology at the School of Medicine at University of Virginia. She earned her PhD at the University of California San Francisco. Her laboratory’s research focuses primarily on the cellular mechanisms of implantation and gastrulation in the mouse embryo and, in particular, the regulation of motility in the trophoblast cells of the implanting mouse blastocyst, and the cell behaviors leading to axial elongation in the mid-gestation embryo.

Table of contents (11 chapters)

  • Egg Activation at Fertilization

    Machaty, Zoltan (et al.)

    Pages 1-47

  • Controlling the Messenger: Regulated Translation of Maternal mRNAs in Xenopus laevis Development

    Sheets, Michael D. (et al.)

    Pages 49-82

  • Regulation of Cell Division

    Heim, Andreas (et al.)

    Pages 83-116

  • Vertebrate Embryonic Cleavage Pattern Determination

    Hasley, Andrew (et al.)

    Pages 117-171

  • Localization in Oogenesis of Maternal Regulators of Embryonic Development

    Escobar-Aguirre, Matias (et al.)

    Pages 173-207

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-3-319-46095-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-319-46093-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-3-319-83439-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Vertebrate Development
Book Subtitle
Maternal to Zygotic Control
Editors
  • Francisco Pelegri
  • Michael Danilchik
  • Ann Sutherland
Series Title
Advances in Experimental Medicine and Biology
Series Volume
953
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-46095-6
DOI
10.1007/978-3-319-46095-6
Hardcover ISBN
978-3-319-46093-2
Softcover ISBN
978-3-319-83439-9
Series ISSN
0065-2598
Edition Number
1
Number of Pages
X, 549
Number of Illustrations
10 b/w illustrations, 71 illustrations in colour
Topics