The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease
Cushing’s Syndrome and Beyond
Editors: Geer, Eliza B. (Ed.)
Free Preview- Explores recent advances in the development of novel medical therapies for the treatment of Cushing’s syndrome
- Provides valuable and cutting edge perspectives on these topics including the concept of “subclinical” adrenal Cushing’s syndrome
- Reviews the pathophysiology of excess cortisol on body composition and metabolism, in particular adipose tissue and bone
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- About this book
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Cushing´s syndrome is a rare disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function, and psychiatric disease, all of which severely reduce quality of life and life expectancy. This book reviews the role of cortisol in the human body, focusing on the effects of excess cortisol due to Cushing’s syndrome as well as the role of the HPA axis in metabolism, inflammation, and neuropsychiatric function. The volume will cover basic mechanistic data, clinical outcomes data, and novel therapies. Also discussed are everything from abnormalities of the HPA axis, to the role of the HPA axis in the development of neuropsychiatric disorders and metabolic disorders, to new definitions of Cushing’s remission and recurrence. The Hypothalamic Pituitary Adrenal Axis in Health and Disease will provide a comprehensive and multi-disciplinary review of the pathophysiology and outcomes of excess cortisol in the human body and brain as well as the role of the HPA axis in other disease states.
- About the authors
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Eliza B. Geer, MD is an endocrinologist at Mount Sinai Medical Center in the Division of Endocrinology with a secondary appointment in the Department of Neurosurgery. After graduating from Columbia University, she attended Mount Sinai School of Medicine, graduating in 2006. Dr. Geer's clinical and research interests include pituitary diseases and neuroendocrinology. She is the principal investigator of a number of studies investigating body composition, adipose tissue regulation, appetite, and long term outcomes in patients with Cushing's Disease and other pituitary diseases. She was awarded the Dr. Harold and Golden Lamport Research Award for Clinical Research in 2012, and the Mount Sinai Endocrinologist of the Year award for outstanding service to the Icahn School of Medicine and Mount Sinai Hospital in 2013.
- Table of contents (15 chapters)
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Glucocorticoid Regulation of Body Composition and Metabolism
Pages 3-26
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Glucocorticoid Regulation of Neurocognitive and Neuropsychiatric Function
Pages 27-41
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Glucocorticoids: Inflammation and Immunity
Pages 43-63
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Molecular Pathogenesis of Primary Adrenal Cushing’s Syndrome
Pages 67-92
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Pathogenesis and Treatment of Aggressive Corticotroph Pituitary Tumors
Pages 93-110
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Table of contents (15 chapters)
- Download Preface 1 PDF (85.3 KB)
- Download Sample pages 1 PDF (256.6 KB)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease
- Book Subtitle
- Cushing’s Syndrome and Beyond
- Editors
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- Eliza B. Geer
- Copyright
- 2017
- Publisher
- Springer International Publishing
- Copyright Holder
- Springer International Publishing Switzerland
- eBook ISBN
- 978-3-319-45950-9
- DOI
- 10.1007/978-3-319-45950-9
- Hardcover ISBN
- 978-3-319-45948-6
- Softcover ISBN
- 978-3-319-83405-4
- Edition Number
- 1
- Number of Pages
- VI, 327
- Number of Illustrations
- 4 b/w illustrations, 15 illustrations in colour
- Topics
