Biochemistry of Oxidative Stress

1. Front Matter

   Pages i-xi

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2. General Aspects

   1. Front Matter

      Pages 1-1

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   2. The Concept of Oxidative Stress After 30 Years

      • Helmut Sies

      Pages 3-11

   3. The Evolution of the Earth and Its Atmosphere

      • Juan José Poderoso

      Pages 13-22

   4. Mitochondria Are the Main Cellular Source of O2 −, H2O2 and Oxidative Stress

      • Alberto Boveris, Marisa G. Repetto

      Pages 23-35

   5. Biochemistry and Physiology of Heart Mitochondrial Nitric Oxide Synthase

      • Tamara Zaobornyj, Darío E. Iglesias, Silvina S. Bombicino, Ivana A. Rukavina-Mikusic, Laura B. Valdez

      Pages 37-48

   6. Biochemistry of Nitric Oxide and Peroxynitrite: Sources, Targets and Biological Implications

      • Adrián Aicardo, Débora M. Martinez, Nicolás Campolo, Silvina Bartesaghi, Rafael Radi

      Pages 49-77

   7. Nitro-arachidonic Acid: Downstream Signaling and Therapeutics

      • Homero Rubbo, Lucía González-Perilli, Mauricio Mastrogiovanni, Beatriz Sánchez-Calvo, Andrés Trostchansky

      Pages 79-93

   8. Mitochondrial Transfer by Intercellular Nanotubes

      • Viviana Sanchez, Alicia Brusco

      Pages 95-108

   9. Human Adaptation to Life at High Altitude

      • Gustavo F. Gonzales, Dulce E. Alarcón-Yaquetto, Alisson Zevallos-Concha

      Pages 109-126

3. Cardiovascular Diseases

   1. Front Matter

      Pages 127-127

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   2. Role of Oxidative Stress in Subcellular Defects in Ischemic Heart Disease

      • Monika Bartekova, Miroslav Barancik, Naranjan S. Dhalla

      Pages 129-146

   3. Reduced Oxidative Stress as a Mechanism for Increased Longevity, Exercise and Heart Failure Protection with Adenylyl Cyclase Type 5 Inhibition

      • Stephen F. Vatner, Jie Zhang, Dorothy E. Vatner

      Pages 147-161

   4. Regulation of Protein Nitrosylation by Thioredoxin 1

      • Narayani Nagarajan, Junichi Sadoshima

      Pages 163-175

   5. Thioredoxin Attenuates Post-ischemic Damage in Ventricular and Mitochondrial Function

      • Veronica D’Annunzio, Virginia Perez, Tamara Mazo, Ricardo Jorge Gelpi

      Pages 177-191

   6. Antioxidant Supplementation in Cardiovascular Disease and Hypertension

      • José Milei, Susana Vila, Francisco Azzato, Giuseppe Ambrosio, Matilde Otero-Losada

      Pages 193-212

   7. Oxidative Stress Influence in the Development of Pulmonary Arterial Hypertension

      • Adriane Belló-Klein, Alex Sander Araujo, Paulo Cavalheiro Schenkel, Bruna Gazzi de Lima Seolin

      Pages 213-226

   8. Redox Regulation of Vascular Remodeling

      • Leonardo Y. Tanaka, Denise de Castro Fernandes, Francisco R. M. Laurindo

      Pages 227-243

   9. Mitochondrial Complex I Inactivation After Ischemia-Reperfusion in the Stunned Heart

      • Laura B. Valdez, Silvina S. Bombicino, Darío E. Iglesias, Ivana A. Rukavina-Mikusic, Verónica D’Annunzio

      Pages 245-257

   10. Reactive Oxygen Species Are Involved in Myocardial Remote Ischemic Preconditioning

       • Martín Donato, Diamela T. Paez, Pablo Evelson, Ricardo Jorge Gelpi

       Pages 259-274

The strongest point of this book titled “Biochemistry of Oxidative Stress: Physiopathology and Clinical Aspects”, is that the academic and scientific background of the authors/editors guarantee the authorship of a book comprising all aspects of oxidative stress, ranging from very molecular aspects, to clinical application, including the antioxidant therapy. Of particular importance is the fact that the aforementioned aspects are described in the book in a general section and in three different and important pathologies, such as cardiovascular diseases, neurodegenerative diseases, and cancer. The importance of these pathologies lays in the fact that, taken separately or together, they represent by far the leading cause of death in the world. Finally, all the chapters have been written by highly recognized authorities in the field of their investigations. At least to our knowledge, this is the first book with this characteristics in the field of oxidative stress.

• Oxidative Stress
• Mammalian Physiology
• Mammalian Physiopathology
• Cardiovascular Diseases
• Neurodegenerative Diseases
• Cancer

• School of Medicine, University of Buenos Aires, Buenos Aires, Argentina

  Ricardo Jorge Gelpi

• School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

  Alberto Boveris

• Instituto de Inmunología, Genética y Metabolismo (INIGEM, UBA–CONICET), Laboratorio de Metabolismo del Oxígeno, Hospital Universitario, Universidad de Buenos Aires, Buenos Aires, Argentina

  Juan José Poderoso

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