Progress in Inflammation Research

The Blood Brain Barrier and Inflammation

Editors: Lyck, Ruth, Enzmann, Gaby (Eds.)

Free Preview
  • Provides a comprehensive overview on the role of the BBB during CNS inflammation
  • Covers inflammatory diseases, like autoimmune and viral induced CNS inflammation, cerebral malaria, multiple sclerosis, bacterial meningitis, and others
  • Presents methods to study neuro-inflammation, employing BBB animal models and imaging techniques
see more benefits

Buy this book

eBook $149.00
price for USA in USD
  • ISBN 978-3-319-45514-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-3-319-45512-9
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $199.99
price for USA in USD
  • ISBN 978-3-319-83308-8
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
About this book

This PIR volume presents a comprehensive collection of reviews that focus on the role of the blood-brain barrier (BBB) during steady-state and inflamed conditions. Within the central nervous system (CNS) the constantly changing bloodstream is strictly separated from the CNS parenchyma by the BBB. However, viruses, bacteria, parasites and auto-aggressive immune cells can penetrate the barrier and significantly contribute to CNS inflammation. The BBB can actively contribute to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alterations of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential to the development of new drugs to efficiently combat inflammatory diseases of the CNS.

About the authors

Ruth Lyck (PD, PhD), group leader, Theodor-Kocher-Institute, Bern, Switzerland, works on extravasation of immune cells or metastasing cancer cells across the blood brain barrier. Gaby Enzmann (PhD), Research Associate, Theodor-Kocher-Institute, Bern, Switzerland, works on immune cell trafficking across the brain barriers into the central nervous system.

Table of contents (11 chapters)

Table of contents (11 chapters)
  • General Introduction to Barrier Mechanisms in the Central Nervous System

    Pages 1-22

    Saunders, Norman R. (et al.)

  • Topological Aspects of the Blood–Brain and Blood–Cerebrospinal Fluid Barriers and Their Relevance in Inflammation

    Pages 23-48

    Pfeiffer, Friederike (et al.)

  • The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions

    Pages 49-60

    Hannocks, Melanie-Jane (et al.)

  • Pathophysiology of the Blood–Brain Barrier in Neuroinflammatory Diseases

    Pages 61-79

    Majerova, Petra (et al.)

  • Leakage at Blood-Neural Barriers

    Pages 81-102

    Turowski, Patric

Buy this book

eBook $149.00
price for USA in USD
  • ISBN 978-3-319-45514-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-3-319-45512-9
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $199.99
price for USA in USD
  • ISBN 978-3-319-83308-8
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Loading...

Bibliographic Information

Bibliographic Information
Book Title
The Blood Brain Barrier and Inflammation
Editors
  • Ruth Lyck
  • Gaby Enzmann
Series Title
Progress in Inflammation Research
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-45514-3
DOI
10.1007/978-3-319-45514-3
Hardcover ISBN
978-3-319-45512-9
Softcover ISBN
978-3-319-83308-8
Series ISSN
0379-0363
Edition Number
1
Number of Pages
VI, 286
Number of Illustrations
8 b/w illustrations, 24 illustrations in colour
Topics