Springer Theses

Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors

Authors: Oberleitner, Maximilian

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  • Doctoral thesis nominated as an outstanding PhD thesis by the University of Regensburg, Germany
  • Describes novel sensors for obtaining dynamic cell response information
  • Applies a variety of analytical methodology for multi-parametric monitoring of cell-based assays
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eBook $129.00
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  • ISBN 978-3-319-45384-2
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Hardcover $169.99
price for USA in USD
  • ISBN 978-3-319-45383-5
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Softcover $169.99
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  • ISBN 978-3-319-83279-1
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About this book

This thesis describes novel substrate embedded physical sensors that can be used to monitor different types of cell-based assays non-invasively and label-free. The sensors described provide integrative information of the cells under study with an adaptable time resolution (ranging from milliseconds to days). This information about the dynamic cell response to chemical, physical or biological stimuli defines a new paradigm in fundamental biomedical research.
The author, Maximilian Oberleitner, describes approaches in which the cells are directly grown on different sensor surfaces (gold-film electrodes, shear wave resonators or dye-doped polymer films). This approach, with the reacting cells in particularly close proximity and contact with the sensor surface, is key to a remarkable sensitivity, opening the way for a variety of new applications. This thesis not only introduces the fundamentals of each approach, but it also describes in great detail the design principles and elucidates the boundary conditions of the new sensors.

About the authors

Maximilian Oberleitner was born in 1983 in Bavaria, Germany and graduated from the University of Regensburg with a Diploma in Chemistry in 2008. Based on this doctoral thesis “Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors” he obtained his PhD in Analytical Chemistry in 2016 in the Institute of Analytical Chemistry, Chemo- and Biosensors at the University of Regensburg under the supervision of Prof. Dr. Joachim Wegener. His research work was focused on the development and improvement of substrate-integrated sensors for the analysis of living cells. These sensors enable the monitoring of cell-substrate interactions and the real-time analysis of assays with adherently grown cells in a non-invasive, label-free and – by combinations of the different types of sensors – even in a multi-parametric manner. Since 2015 he works at a global healthcare company in Austria. As project leader in the quality unit he is responsible for stability studies and quality evaluations of antibiotics.

Table of contents (7 chapters)

Table of contents (7 chapters)

Buy this book

eBook $129.00
price for USA in USD
  • ISBN 978-3-319-45384-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA in USD
  • ISBN 978-3-319-45383-5
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $169.99
price for USA in USD
  • ISBN 978-3-319-83279-1
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors
Authors
Series Title
Springer Theses
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-45384-2
DOI
10.1007/978-3-319-45384-2
Hardcover ISBN
978-3-319-45383-5
Softcover ISBN
978-3-319-83279-1
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XXVI, 370
Number of Illustrations
16 b/w illustrations, 122 illustrations in colour
Topics