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Advances in Experimental Medicine and Biology

DNA Methyltransferases - Role and Function

Editors: Jeltsch, Albert, Jurkowska, Renata Z. (Eds.)

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  • Offers comprehensive insights into the newest findings in the field of DNA methylation 
  • Provides in depth knowledge on the structure, enzymatic mechanism as well as the biological roles of DNA methyltransferases
  • Discusses related processes like reading of DNA methylation and DNA demethylation 
  • Broadens the understanding on the role of DNA methyltransferases in human diseases 
  • Chapters written by leading experts in the field
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eBook $189.00
price for USA in USD (gross)
  • ISBN 978-3-319-43624-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-319-43622-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-3-319-82870-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

DNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and describes the role of DNA methylation in diseases. Moreover, the book explains modern technologies, like targeted rewriting of DNA methylation by designed DNA methyltransferases, as well as technological applications of DNA methyltransferases in DNA labelling. Finally, the book summarizes recent methods for the analysis of DNA methylation in human DNA. Overall, this book represents a comprehensive state-of-the-art- work and is a must-have for advanced researchers in the field of DNA methylation and epigenetics.

About the authors

Albert Jeltsch is Pofessor for Biochemistry at the University of Stuttgart, Germany.

Renata Jurkowska is Group Leader in Biochemistry and Molecular Epigenetics at the University of Stuttgart, Germany.

Table of contents (19 chapters)

Table of contents (19 chapters)
  • Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges

    Pages 1-17

    Jurkowska, Renata Z. (et al.)

  • DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position

    Pages 19-33

    Motorin, Yuri (et al.)

  • Bacterial DNA Methylation and Methylomes

    Pages 35-61

    Casadesús, Josep

  • Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases

    Pages 63-86

    Tajima, Shoji (et al.)

  • Enzymology of Mammalian DNA Methyltransferases

    Pages 87-122

    Jurkowska, Renata Z. (et al.)

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-3-319-43624-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-319-43622-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-3-319-82870-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
DNA Methyltransferases - Role and Function
Editors
  • Albert Jeltsch
  • Renata Z. Jurkowska
Series Title
Advances in Experimental Medicine and Biology
Series Volume
945
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-43624-1
DOI
10.1007/978-3-319-43624-1
Hardcover ISBN
978-3-319-43622-7
Softcover ISBN
978-3-319-82870-1
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VIII, 535
Number of Illustrations
4 b/w illustrations, 57 illustrations in colour
Topics