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DNA Methyltransferases - Role and Function

  • Book
  • © 2016

Overview

Editors:
  1. Albert Jeltsch

    1. Institut für Biochemie, Universität Stuttgart, Stuttgart, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Renata Z. Jurkowska

    1. BioMed X Innovation Center, Heidelberg, Germany

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    You can also search for this editor in PubMed   Google Scholar

  • Offers comprehensive insights into the newest findings in the field of DNA methylation
  • Provides in depth knowledge on the structure, enzymatic mechanism as well as the biological roles of DNA methyltransferases
  • Discusses related processes like reading of DNA methylation and DNA demethylation
  • Broadens the understanding on the role of DNA methyltransferases in human diseases
  • Chapters written by leading experts in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 945)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-viii
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  2. Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges

    • Renata Z. Jurkowska, Albert Jeltsch
    Pages 1-17

  3. DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position

    • Yuri Motorin, Salifu Seidu-Larry, Mark Helm
    Pages 19-33

  4. Bacterial DNA Methylation and Methylomes

    • Josep Casadesús
    Pages 35-61

  5. Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases

    • Shoji Tajima, Isao Suetake, Kohei Takeshita, Atsushi Nakagawa, Hironobu Kimura
    Pages 63-86

  6. Enzymology of Mammalian DNA Methyltransferases

    • Renata Z. Jurkowska, Albert Jeltsch
    Pages 87-122

  7. Genetic Studies on Mammalian DNA Methyltransferases

    • Jiameng Dan, Taiping Chen
    Pages 123-150

  8. The Role of DNA Methylation in Cancer

    • Ranjani Lakshminarasimhan, Gangning Liang
    Pages 151-172

  9. Structure and Mechanism of Plant DNA Methyltransferases

    • Jiamu Du
    Pages 173-192

  10. DNA Methylation and Gene Regulation in Honeybees: From Genome-Wide Analyses to Obligatory Epialleles

    • Laura Wedd, Ryszard Maleszka
    Pages 193-211

  11. N6-Methyladenine: A Conserved and Dynamic DNA Mark

    • Zach Klapholz O’Brown, Eric Lieberman Greer
    Pages 213-246

  12. Pathways of DNA Demethylation

    • Wendy Dean
    Pages 247-274

  13. Structure and Function of TET Enzymes

    • Xiaotong Yin, Yanhui Xu
    Pages 275-302

  14. Proteins That Read DNA Methylation

    • Takashi Shimbo, Paul A. Wade
    Pages 303-320

  15. DNA Base Flipping: A General Mechanism for Writing, Reading, and Erasing DNA Modifications

    • Samuel Hong, Xiaodong Cheng
    Pages 321-341

  16. Current and Emerging Technologies for the Analysis of the Genome-Wide and Locus-Specific DNA Methylation Patterns

    • Jörg Tost
    Pages 343-430

  17. DNA Methyltransferase Inhibitors: Development and Applications

    • Marie Lopez, Ludovic Halby, Paola B. Arimondo
    Pages 431-473

  18. Rewriting DNA Methylation Signatures at Will: The Curable Genome Within Reach?

    • Sabine Stolzenburg, Désirée Goubert, Marianne G. Rots
    Pages 475-490

  19. Engineering and Directed Evolution of DNA Methyltransferases

    • Paola Laurino, Liat Rockah-Shmuel, Dan S. Tawfik
    Pages 491-509

  20. DNA Labeling Using DNA Methyltransferases

    • Miglė Tomkuvienė, Edita Kriukienė, Saulius Klimašauskas
    Pages 511-535
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Keywords

About this book

DNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and describes the role of DNA methylation in diseases. Moreover, the book explains modern technologies, like targeted rewriting of DNA methylation by designed DNA methyltransferases, as well as technological applications of DNA methyltransferases in DNA labelling. Finally, the book summarizes recent methods for the analysis of DNA methylation in human DNA. Overall, this book represents a comprehensive state-of-the-art- work and is a must-havefor advanced researchers in the field of DNA methylation and epigenetics.

Editors and Affiliations

  • Institut für Biochemie, Universität Stuttgart, Stuttgart, Germany

    Albert Jeltsch

  • BioMed X Innovation Center, Heidelberg, Germany

    Renata Z. Jurkowska

About the editors

Albert Jeltsch is Pofessor for Biochemistry at the University of Stuttgart, Germany.

Renata Jurkowska is Group Leader in Biochemistry and Molecular Epigenetics at the University of Stuttgart, Germany.

Bibliographic Information

  • Book Title: DNA Methyltransferases - Role and Function

  • Editors: Albert Jeltsch, Renata Z. Jurkowska

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-43624-1

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016

  • Hardcover ISBN: 978-3-319-43622-7Published: 22 November 2016

  • Softcover ISBN: 978-3-319-82870-1Published: 06 July 2018

  • eBook ISBN: 978-3-319-43624-1Published: 08 November 2016

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 535

  • Number of Illustrations: 4 b/w illustrations, 57 illustrations in colour

  • Topics: Cell Biology, Gene Expression, Cytogenetics

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