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Fundamental Biomedical Technologies

Intracellular Delivery III

Market Entry Barriers of Nanomedicines

Editors: Prokop, Aleš, Weissig, Volkmar (Eds.)

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  • Comprehensive set of reviews dealing with cellular (tissue) and intracellular targeting of nanovehicles
  • Covers classical and computational means of nanovehicle targeting
  • Delivers important application areas in medicine
  • Written by world experts in this field
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About this book

A critical review is attempted to assess the status of nanomedicine entry onto the market. The emergence of new potential therapeutic entities such as DNA and RNA fragments requires that these new “drugs” will need to be delivered in a cell-and organelle-specific manner. Although efforts have been made over the last 50 years or so to develop such delivery technology, no effective and above all clinically approved protocol for cell-specific drug delivery in humans exists as yet. Various particles, macromolecules, liposomes and most recently “nanomaterials” have been said to “show promise” but none of these promises have so far been “reduced” to human clinical practice. The focus of this volume is on cancer indication since the majority of published research relates to this application; within that, we focus on solid tumors (solid malignancies). Our aim is critically to evaluate whether nanomaterials, both non-targeted and targeted to specific cells, could be of therapeutic benefit in clinical practice. The emphasis of this volume will be on pharmacokinetics (PK) and pharmacodynamics (PD) in animal and human studies. Apart from the case of exquisitely specific antibody-based drugs, the development of target-specific drug–carrier delivery systems has not yet been broadly successful at the clinical level. It can be argued that drugs generated using the conventional means of drug development (i.e., relying on facile biodistribution and activity after (preferably) oral administration) are not suitable for a target-specific delivery and would not benefit from such delivery even when a seemingly perfect delivery system is available. Therefore, successful development of site-selective drug delivery systems will need to include not only the development of suitable carriers, but also the development of drug entities that meet the required PK/PD profile. 

Table of contents (17 chapters)

Table of contents (17 chapters)
  • Overview of Present Problems Facing Commercialization of Nanomedicines

    Pages 3-36

    Prokop, Aleš (et al.)

  • Precision Drugs and Cell-Specific Drug Delivery

    Pages 37-46

    Petrak, Karel

  • Extracellular Matrix Degrading Enzymes for Nanocarrier-Based Anticancer Therapy

    Pages 49-66

    Scodeller, Pablo

  • Nanocarrier-Based Anticancer Therapies with the Focus on Strategies for Targeting the Tumor Microenvironment

    Pages 67-122

    Leonard, Fransisca (et al.)

  • A New Approach to Decrease the RES Uptake of Nanodrugs by Pre-administration with Intralipid® Resulting in a Reduction of Toxic Side Effects

    Pages 125-146

    Liu, Li (et al.)

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-3-319-43525-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-3-319-43523-7
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-3-319-82846-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Intracellular Delivery III
Book Subtitle
Market Entry Barriers of Nanomedicines
Editors
  • Aleš Prokop
  • Volkmar Weissig
Series Title
Fundamental Biomedical Technologies
Series Volume
8
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-43525-1
DOI
10.1007/978-3-319-43525-1
Hardcover ISBN
978-3-319-43523-7
Softcover ISBN
978-3-319-82846-6
Series ISSN
1559-7083
Edition Number
1
Number of Pages
XIII, 453
Number of Illustrations
16 b/w illustrations, 65 illustrations in colour
Topics

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