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Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance

  • Book
  • © 2016

Overview

Editors:
  1. Judith Blaine

    1. Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, USA

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  • Provides a complete overview of the renal handling of albumin

  • Includes discussion of albumin handling at the molecular level and details epidemiological studies

  • Highlights the advanced imaging techniques including intravital microscopy

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-vii
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  2. Evaluation and Epidemiology of Proteinuria

    • Judith Blaine
    Pages 1-9

  3. Glomerular Mechanisms of Proteinuria

    • Evgenia Dobrinskikh, Judith Blaine
    Pages 11-21

  4. Tubular Mechanisms in Proteinuria

    • Sudhanshu K. Verma, Bruce A. Molitoris
    Pages 23-40

  5. Pathophysiology of Diabetic Nephropathy

    • Michal Herman-Edelstein, Sonia Q. Doi
    Pages 41-65

  6. Immune-Mediated Mechanisms of Proteinuria

    • Lindsey Goetz, Joshua M. Thurman
    Pages 67-84

  7. Minimal Change Disease

    • Gabriel M. Cara-Fuentes, Richard J. Johnson, Eduardo H. Garin
    Pages 85-116

  8. Focal Segmental Glomerulosclerosis and Its Pathophysiology

    • James Dylewski, Judith Blaine
    Pages 117-139

  9. Back Matter

    Pages 141-145
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Keywords

About this book

Recent work has begun to elucidate at the molecular level how albumin is handled by the kidney and how albuminuria develops in various proteinuric diseases including minimal change disease and focal segmental glomerulosclerosis. This volume provides a comprehensive overview of the renal handling of albumin – from basic mechanisms to the pathophysiology of proteinuric diseases. In describing the basic mechanisms of albuminuria, a particular highlight will be the focus on  advanced imaging techniques such as intravital microscopy that have allowed a detailed “window” into albumin transit through the kidney.   The volume will cover the epidemiological studies which show that albuminuria is a strong and independent marker of kidney disease progression and cardiovascular events, the molecular details of albumin handling in the kidney at the level of the glomerulus and the proximal tubule and the pathophysiology of proteinuric diseases including minimal change disease, membranous nephropathy, focal segmental glomerulosclerosis and diabetic nephropathy.

Editors and Affiliations

  • Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, USA

    Judith Blaine

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