Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance

1. Front Matter

   Pages i-vii

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2. Evaluation and Epidemiology of Proteinuria

   • Judith Blaine

   Pages 1-9

3. Glomerular Mechanisms of Proteinuria

   • Evgenia Dobrinskikh, Judith Blaine

   Pages 11-21

4. Tubular Mechanisms in Proteinuria

   • Sudhanshu K. Verma, Bruce A. Molitoris

   Pages 23-40

5. Pathophysiology of Diabetic Nephropathy

   • Michal Herman-Edelstein, Sonia Q. Doi

   Pages 41-65

6. Immune-Mediated Mechanisms of Proteinuria

   • Lindsey Goetz, Joshua M. Thurman

   Pages 67-84

7. Minimal Change Disease

   • Gabriel M. Cara-Fuentes, Richard J. Johnson, Eduardo H. Garin

   Pages 85-116

8. Focal Segmental Glomerulosclerosis and Its Pathophysiology

   • James Dylewski, Judith Blaine

   Pages 117-139

9. Back Matter

   Pages 141-145

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Recent work has begun to elucidate at the molecular level how albumin is handled by the kidney and how albuminuria develops in various proteinuric diseases including minimal change disease and focal segmental glomerulosclerosis. This volume provides a comprehensive overview of the renal handling of albumin – from basic mechanisms to the pathophysiology of proteinuric diseases. In describing the basic mechanisms of albuminuria, a particular highlight will be the focus on  advanced imaging techniques such as intravital microscopy that have allowed a detailed “window” into albumin transit through the kidney.   The volume will cover the epidemiological studies which show that albuminuria is a strong and independent marker of kidney disease progression and cardiovascular events, the molecular details of albumin handling in the kidney at the level of the glomerulus and the proximal tubule and the pathophysiology of proteinuric diseases including minimal change disease, membranous nephropathy, focal segmental glomerulosclerosis and diabetic nephropathy.

• Proteinuria
• diabetic nephropathy
• kidney disease
• membranous nephropathy
• podocyte biology
• Protein Structure

• Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, USA

  Judith Blaine

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