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Resistance to Targeted Anti-Cancer Therapeutics

Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy

Editors: Donnadieu, Emmanuel (Ed.)

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  • Gives the latest research on specific defects in T cell trafficking, which hinder the success of cancer immunotherapy
  • Provides the basic priniciples to T cell migration during efficient immune responses
  • Explores therapeutic interventions to promote T cell migration into tumors
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eBook $139.00
price for USA in USD (gross)
  • ISBN 978-3-319-42223-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-319-42221-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-3-319-82528-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

About the authors

Emmanuel Donnadieu, Ph.D, is a researcher and team leader of the 'Dynamics of T cell Interactions' group at the Cochin Institute. His recent research include breakthroughs in newly developed methods for following the migration and activation patterns of lymphocytes and other immune cells within tumors.

Table of contents (8 chapters)

Table of contents (8 chapters)
  • Basic Rules of T Cell Migration

    Pages 1-19

    Stein, Jens V. (et al.)

  • Regulation of Anti-tumor T Cell Migration and Function: Contribution of Real-Time Imaging

    Pages 21-49

    Loyher, Pierre-Louis (et al.)

  • Vascular Normalization, T Cell Trafficking and Anti-tumor Immunity

    Pages 51-76

    Fabian, Kellsye L. (et al.)

  • Disruption of Anti-tumor T Cell Responses by Cancer-Associated Fibroblasts

    Pages 77-98

    Pommier, Arnaud (et al.)

  • Cancer-Associated Tertiary Lymphoid Structures, from Basic Knowledge Toward Therapeutic Target in Clinic

    Pages 99-125

    Dubois, Bertrand (et al.)

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-3-319-42223-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA in USD
  • ISBN 978-3-319-42221-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $179.99
price for USA in USD
  • ISBN 978-3-319-82528-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy
Editors
  • Emmanuel Donnadieu
Series Title
Resistance to Targeted Anti-Cancer Therapeutics
Series Volume
9
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-42223-7
DOI
10.1007/978-3-319-42223-7
Hardcover ISBN
978-3-319-42221-3
Softcover ISBN
978-3-319-82528-1
Series ISSN
2196-5501
Edition Number
1
Number of Pages
VIII, 199
Number of Illustrations
8 b/w illustrations, 19 illustrations in colour
Topics