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Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy

  • Book
  • © 2016

Overview

Editors:
  1. Emmanuel Donnadieu

    1. Institut Cochin INSERM, Université Paris Descartes, Paris, France

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  • Gives the latest research on specific defects in T cell trafficking, which hinder the success of cancer immunotherapy
  • Provides the basic priniciples to T cell migration during efficient immune responses
  • Explores therapeutic interventions to promote T cell migration into tumors
  • Includes supplementary material: sn.pub/extras

Part of the book series: Resistance to Targeted Anti-Cancer Therapeutics (RTACT, volume 9)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-viii
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  2. Basic Rules of T Cell Migration

    • Jens V. Stein, Federica Moalli, Markus Ackerknecht
    Pages 1-19

  3. Regulation of Anti-tumor T Cell Migration and Function: Contribution of Real-Time Imaging

    • Pierre-Louis Loyher, Christophe Combadière, Alexandre Boissonnas
    Pages 21-49

  4. Vascular Normalization, T Cell Trafficking and Anti-tumor Immunity

    • Kellsye L. Fabian, Walter J. Storkus
    Pages 51-76

  5. Disruption of Anti-tumor T Cell Responses by Cancer-Associated Fibroblasts

    • Arnaud Pommier, Douglas T. Fearon
    Pages 77-98

  6. Cancer-Associated Tertiary Lymphoid Structures, from Basic Knowledge Toward Therapeutic Target in Clinic

    • Bertrand Dubois, Hélène Kaplon, Coline Couillault, Christophe Caux, Marie-Caroline Dieu-Nosjean
    Pages 99-125

  7. Homing Improvement: Boosting T Cell Trafficking for Cancer Immunotherapy

    • Joseph M. Cantor
    Pages 127-161

  8. Chemokines and T Cell Trafficking into Tumors: Strategies to Enhance Recruitment of T Cells into Tumors

    • Stefano Garetto, Claudia Sardi, Diego Morone, Marinos Kallikourdis
    Pages 163-177

  9. Strategies to Enhance Migration and Persistence of Chimeric Antigen Receptor (CAR)-T Cells into Tumors

    • Yuhui Chen, Gianpietro Dotti, Barbara Savoldo
    Pages 179-193

  10. Back Matter

    Pages 195-199
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Keywords

About this book

This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

Editors and Affiliations

  • Institut Cochin INSERM, Université Paris Descartes, Paris, France

    Emmanuel Donnadieu

About the editor

Emmanuel Donnadieu, Ph.D, is a researcher and team leader of the 'Dynamics of T cell Interactions' group at the Cochin Institute. His recent research include breakthroughs in newly developed methods for following the migration and activation patterns of lymphocytes and other immune cells within tumors.

Bibliographic Information

  • Book Title: Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy

  • Editors: Emmanuel Donnadieu

  • Series Title: Resistance to Targeted Anti-Cancer Therapeutics

  • DOI: https://doi.org/10.1007/978-3-319-42223-7

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-42221-3Published: 06 September 2016

  • Softcover ISBN: 978-3-319-82528-1Published: 22 April 2018

  • eBook ISBN: 978-3-319-42223-7Published: 30 August 2016

  • Series ISSN: 2196-5501

  • Series E-ISSN: 2196-551X

  • Edition Number: 1

  • Number of Pages: VIII, 199

  • Number of Illustrations: 8 b/w illustrations, 19 illustrations in colour

  • Topics: Cancer Research, Immunology, Molecular Medicine

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