Overview
- Covers the latest progress in the understanding of the molecular events governing the signaling of Adhesion GPCRs, a large group of enigmatic receptors in the GPCR superfamily, and their physiological properties
- Discusses the newly discovered activation mode of Adhesion GPCRs and their metabotropic activity profile
- Highlights the evidence suggesting that Adhesion GPCRs detect mechanical stimuli
Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 234)
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Table of contents (18 chapters)
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Front Matter
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Molecular and Pharmacological Properties of Adhesion GPCRs
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Front Matter
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Adhesion GPCRs as Pharmakotargets in Organ Function and Development
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Front Matter
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Keywords
About this book
Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.
Editors and Affiliations
Bibliographic Information
Book Title: Adhesion G Protein-coupled Receptors
Book Subtitle: Molecular, Physiological and Pharmacological Principles in Health and Disease
Editors: Tobias Langenhan, Torsten Schöneberg
Series Title: Handbook of Experimental Pharmacology
DOI: https://doi.org/10.1007/978-3-319-41523-9
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG 2016
Hardcover ISBN: 978-3-319-41521-5Published: 22 November 2016
Softcover ISBN: 978-3-319-82375-1Published: 23 June 2018
eBook ISBN: 978-3-319-41523-9Published: 09 November 2016
Series ISSN: 0171-2004
Series E-ISSN: 1865-0325
Edition Number: 1
Number of Pages: XIV, 403
Number of Illustrations: 1 b/w illustrations, 67 illustrations in colour
Topics: Pharmacology/Toxicology, Human Physiology, Human Genetics, Cell Biology, Medical Biochemistry