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Handbook of Experimental Pharmacology

Adhesion G Protein-coupled Receptors

Molecular, Physiological and Pharmacological Principles in Health and Disease

Editors: Langenhan, Tobias, Schöneberg, Torsten (Eds.)

  • Covers the latest progress in the understanding of the molecular events governing the signaling of Adhesion GPCRs, a large group of enigmatic receptors in the GPCR superfamily, and their physiological properties
  • Discusses the newly discovered activation mode of Adhesion GPCRs and their metabotropic activity profile
  • Highlights the evidence suggesting that Adhesion GPCRs detect mechanical stimuli
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eBook $269.00
price for USA in USD (gross)
  • ISBN 978-3-319-41523-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.99
price for USA in USD
  • ISBN 978-3-319-41521-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $349.99
price for USA in USD
  • ISBN 978-3-319-82375-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.

Table of contents (18 chapters)

  • Introduction: History of the Adhesion GPCR Field

    Hamann, Jörg (et al.)

    Pages 1-11

  • Classification, Nomenclature, and Structural Aspects of Adhesion GPCRs

    Krishnan, Arunkumar (et al.)

    Pages 15-41

  • 7TM Domain Structure of Adhesion GPCRs

    Nijmeijer, Saskia (et al.)

    Pages 43-66

  • Understanding the Structural Basis of Adhesion GPCR Functions

    Araç, Demet (et al.)

    Pages 67-82

  • Control of Adhesion GPCR Function Through Proteolytic Processing

    Nieberler, Matthias (et al.)

    Pages 83-109

Buy this book

eBook $269.00
price for USA in USD (gross)
  • ISBN 978-3-319-41523-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $349.99
price for USA in USD
  • ISBN 978-3-319-41521-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $349.99
price for USA in USD
  • ISBN 978-3-319-82375-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Adhesion G Protein-coupled Receptors
Book Subtitle
Molecular, Physiological and Pharmacological Principles in Health and Disease
Editors
  • Tobias Langenhan
  • Torsten Schöneberg
Series Title
Handbook of Experimental Pharmacology
Series Volume
234
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-41523-9
DOI
10.1007/978-3-319-41523-9
Hardcover ISBN
978-3-319-41521-5
Softcover ISBN
978-3-319-82375-1
Series ISSN
0171-2004
Edition Number
1
Number of Pages
XIV, 403
Number of Illustrations
1 b/w illustrations, 67 illustrations in colour
Topics