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Polymer Nanoparticles for Nanomedicines

A Guide for their Design, Preparation and Development

  • Book
  • © 2016

Overview

Editors:
  1. Christine Vauthier

    1. Institut Galien Paris Sud, Faculty of Pharmacy, CNRS, University of Paris-Sud, University Paris Saclay, Châtenay-Malabry Cedex, France

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  2. Gilles Ponchel

    1. Institut Galien Paris Sud, Faculty of Pharmacy, CNRS, University of Paris-Sud, University Paris Saclay, Châtenay-Malabry Cedex, France

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  • Essential resource for the development of nanomedicines made from polymer nanoparticles

  • Gives concrete advice on how to generate and manufacture polymer nanoparticles, as well as how to adjust their physicochemical properties

  • Presents practical guidelines from renowned experts in the field

  • Includes supplementary material: sn.pub/extras

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xxix
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  2. Methods for the Manufacturing of Nanoparticles: Principles

    1. Front Matter

      Pages 1-1
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    2. Polymer Nanoparticles for In Vivo Applications: Progress on Preparation Methods and Future Challenges

      • Christine Vauthier
      Pages 3-16

    3. Nanoprecipitation Process: From Particle Preparation to In Vivo Applications

      • Karim Miladi, Sana Sfar, Hatem Fessi, Abdelhamid Elaissari
      Pages 17-53

    4. Targeted Theragnostic Nanoparticles Via Flash Nanoprecipitation: Principles of Material Selection

      • Christina Tang, Robert K. Prud’homme
      Pages 55-85

    5. Preparation of Polymer Nanoparticles by the Emulsification-Solvent Evaporation Method: From Vanderhoff’s Pioneer Approach to Recent Adaptations

      • Néstor Mendoza-Muñoz, Sergio Alcalá-Alcalá, David Quintanar-Guerrero
      Pages 87-121

    6. Methods for the Preparation of Nanoparticles by Polymerization

      • Christine Vauthier
      Pages 123-157

    7. Shape-Controlled Nanoparticles for Drug Delivery and Targeting Applications

      • Gilles Ponchel, Olivier Cauchois
      Pages 159-184

  3. Characterization of Polymer Nanoparticles Designed as Nanomedicines

    1. Front Matter

      Pages 185-185
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    2. Physicochemical Characterization of Polymer Nanoparticles: Challenges and Present Limitations

      • Jeffrey D. Clogston, Rachael M. Crist, Scott E. McNeil
      Pages 187-203

    3. Imaging Polymer Nanoparticles by Means of Transmission and Scanning Electron Microscopy Techniques

      • Nicolas Tsapis
      Pages 205-219

    4. Evaluating the Interactions Between Proteins and Components of the Immune System with Polymer Nanoparticles

      • Silvia Lorenzo-Abalde, Rosana Simón-Vázquez, Mercedes Peleteiro Olmedo, Tamara Lozano-Fernández, Olivia Estévez-Martínez, Andrea Fernández-Carrera et al.
      Pages 221-289

    5. Investigating Interactions Between Nanoparticles and Cells: Internalization and Intracellular Trafficking

      • Hervé Hillaireau
      Pages 291-323

  4. Turning Polymer Nanoparticle Technologies into Nanomedicines

    1. Front Matter

      Pages 325-325
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    2. Designing Polymer Nanoparticle Nanomedicines: Potential Applications and Challenges

      • Christine Vauthier
      Pages 327-341

    3. Selecting and Designing Polymers Suitable for Nanoparticle Manufacturing

      • Sandrine Cammas-Marion
      Pages 343-379

    4. Associating Drugs with Polymer Nanoparticles: A Challenge

      • Christelle Zandanel, Christine Charrueau
      Pages 381-437

    5. Drug Delivery by Polymer Nanoparticles: The Challenge of Controlled Release and Evaluation

      • Christine Charrueau, Christelle Zandanel
      Pages 439-503

    6. Interaction Between Nanoparticles and Plasma Proteins: Effects on Nanoparticle Biodistribution and Toxicity

      • Anna N. Ilinskaya, Marina A. Dobrovolskaia
      Pages 505-520

    7. Toxicological Aspects of Polymer Nanoparticles

      • Juan M. Irache, Nekane Martín-Arbella, Patricia Ojer, Amaya Azqueta, Adela Lopez de Cerain
      Pages 521-550
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Keywords

About this book

This volume serves as a valuable handbook for the development of nanomedicines made of polymer nanoparticles because it provides researchers, students, and entrepreneurs with all the material necessary to begin their own projects in this field. Readers will find protocols to prepare polymer nanoparticles using different methods, since these are based on the variety of experiences that experts encounter in the field. In addition, complex topics such as, the optimal characterization of polymer nanoparticles is discussed, as well as practical guidelines on how to formulate polymer nanoparticles into nanomedicines, and how to modify the properties of nanoparticles to give them the different functionalities required to become an efficient nanomedicine for different clinical applications. The book also discusses the translation of technology from research to practice, considering aspects related to industrialization of preparation and aspects of regulatory and clinical development.

Editors and Affiliations

  • Institut Galien Paris Sud, Faculty of Pharmacy, CNRS, University of Paris-Sud, University Paris Saclay, Châtenay-Malabry Cedex, France

    Christine Vauthier, Gilles Ponchel

About the editors

Christine Vauthier is Director of Research at the CNRS (Centre National de la Recherche Scientifique) at the Institut Galien Paris Sud, Université Paris-Sud, France. Dr. Vauthier also serves as an editor for the journal Pharmaceutical Research. She received her Ph. D. in polymer chemistry from the University Louis Pasteur at Strasbourg, France.  She then joined the University of Paris South, Faculty of Pharmacy as a research assistant. The focus of her research is about understanding the influence of the physicochemical characteristics of nanomedicines and their interactions with biological systems when the nanomedicines are intended to improve drug delivery after mucosal or intravenous administration. She is author and co-author of more than 120 research papers as well as over 20 review papers and book chapters on nanoparticle preparation, characterization methods, and on the application of nanoparticles as drug delivery systems. Dr. Vauthier has spoken at numerous conferences and has presented over 100 communications. 

Prof. Gilles Ponchel is full professor at the University of Paris-South where he teaches Pharmaceutical Technology and Biopharmacy. He leads a multidisciplinary research team that belongs to the Institut Galien Université Paris-Sud and specializes in the field of drug delivery. The aim of the team is to conceive and to develop innovative drug delivery systems that can improve the crossing of active drugs through physico-chemical and biological barriers. His main research interests are: (i) the development and the evaluation of bioadhesive delivery systems and (ii) the conception of pharmaceutically acceptable nanomedecines, mainly multifunctionalized nanoparticles prepared from tailored polymers, polypeptides, cyclodextrins, etc. for optimizing their biodistribution in the context of drug targeting applications. Prof. Ponchel is the author of over 130 research papers, more than 170 communications, more than 50 invited lectures. He has been co-author and contributor to books and many book chapters.

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