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Advances in Experimental Medicine and Biology

Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract

Editors: Jansen, Marnix, Wright, Nicholas (Eds.)

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  • Reviews the pathology of early gastric cancers
  • ​Explores the stem cell biology in the context of upper gastrointestinal cancers
  • Discusses therapeutic modalities in esophageal squamous cell carcinoma and early esophageal cancer
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  • ISBN 978-3-319-41388-4
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Softcover $249.99
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  • ISBN 978-3-319-82341-6
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About this book

This book  is a comprehensive understanding of the evolution of pre-malignant disease, emphasizing common themes in the field, including stem cell biology and histologic modes of cancer progression between the distal esophagus and stomach. Its sixteen chapters discuss metaplastic tissue change in the upper GI, clonalexpansion of early neoplasia, stem cell dynamics in experimental models, pathology of early esophageal squamous cell carcinoma, therapeutic modalities for esophageal squamous cell carcinoma, pathology of Barrett’s esophagus, screening, early detection and novel diagnostic tools for Barrett's esophagus, clonal evolution of Barrett’s esophagus, endoscopic therapeutic modalities of early esophageal cancer, pathology of early gastric cancer, and experimental models for gastric cancer.

Stem Cells, Pre-neoplasia and Early Cancer of the Upper Gastrointestinal Tract  is an integrative text on both the current state of translational research on every cancer development of the upper gastrointestinal tract as well as on novel clinical diagnostic and therapeutic modalities. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike. Springer’s Advances in Experimental Medicine and Biology series presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research.

About the authors

Professor Sir Nicholas Wright’s research is in the field of gastrointestinal stem cells and cancer. He was Professor of Pathology at the Royal Postgraduate Medical School at the Hammersmith Hospital, and then became the Dean of the Royal Postgraduate Medical School before becoming the Deputy Principal of the Imperial College School of Medicine in 1998. Sir Nicholas then served as Warden of Barts and the London, Queen Mary’s School of Medicine and Dentistry from 2001 to 2011. He as served as Group Leader at the Histopathology Unit at Cancer Research UK London Research Institute and was President of the Pathological Society of Great Britain and Ireland and the British Society of Gastroenterology. He was knighted in 2006 for services to medicine. Sir Wright has published over 427 scientific articles and received over 12,939 citations.

Dr. Marnix Jansen is a histopathologist at University College London Hospital (UCLH) and Senior Clinical Fellow at Barts Cancer Institute. He a rising young star in the area of upper GI cancer research and he has published 23 scientific papers and has received over 794 citations.

Table of contents (23 chapters)

Table of contents (23 chapters)
  • Distal Esophageal Adenocarcinoma and Gastric Adenocarcinoma: Time for a Shared Research Agenda

    Pages 1-8

    Jansen, Marnix, M.D., Ph.D., M.Sc. (et al.)

  • Clonal Evolution of Stem Cells in the Gastrointestinal Tract

    Pages 11-25

    Fink, Juergen (et al.)

  • The Complex, Clonal, and Controversial Nature of Barrett’s Esophagus

    Pages 27-40

    Evans, James A. (et al.)

  • A New Pathologic Assessment of Gastroesophageal Reflux Disease: The Squamo-Oxyntic Gap

    Pages 41-78

    Chandrasoma, Parakrama, M.D., M.R.C.P. (et al.)

  • Diagnosis by Endoscopy and Advanced Imaging of Barrett’s Neoplasia

    Pages 81-98

    Swager, Anne-Fré, M.D. (et al.)

Buy this book

eBook $189.00
price for USA in USD
  • ISBN 978-3-319-41388-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-319-41386-0
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually ready to be dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-3-319-82341-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually ready to be dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract
Editors
  • Marnix Jansen
  • Nicholas Wright
Series Title
Advances in Experimental Medicine and Biology
Series Volume
908
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-41388-4
DOI
10.1007/978-3-319-41388-4
Hardcover ISBN
978-3-319-41386-0
Softcover ISBN
978-3-319-82341-6
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XII, 486
Number of Illustrations
110 illustrations in colour
Topics

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