SpringerBriefs in Immunology

Interleukin-27: Biological Properties and Clinical Application

Authors: Jankowski, Marek, Wandtke, Tomasz

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  • ISBN 978-3-319-39664-4
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About this book

This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.

Table of contents (3 chapters)

Table of contents (3 chapters)

Buy this book

eBook $54.99
price for USA in USD (gross)
  • ISBN 978-3-319-39664-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $69.99
price for USA in USD
  • ISBN 978-3-319-39662-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Interleukin-27: Biological Properties and Clinical Application
Authors
Series Title
SpringerBriefs in Immunology
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
The Author(s)
eBook ISBN
978-3-319-39664-4
DOI
10.1007/978-3-319-39664-4
Softcover ISBN
978-3-319-39662-0
Series ISSN
2194-2773
Edition Number
1
Number of Pages
VI, 86
Number of Illustrations
5 illustrations in colour
Topics