Skip to main content
SpringerLink
Log in

The Functional Nucleus

  • Book
  • © 2016

Overview

Editors:
  1. David P. Bazett-Jones

    1. Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Graham Dellaire

    1. Dalhousie University, Halifax, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides a state-of-the-art review on nuclear structure and functions
  • Highlights the relation between epigenomics and nuclear architecture
  • Gives an outlook on possible medical applications

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (21 chapters)

  1. Front Matter

    Pages i-vi
    Download chapter PDF

  2. Nuclear Periphery

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Human Diseases Related to Nuclear Envelope Proteins

      • Howard J. Worman
      Pages 3-25

  3. Nuclear Bodies

    1. Front Matter

      Pages 27-27
      Download chapter PDF

    2. The Nucleolus: Structure and Function

      • Marie-Line Dubois, François-Michel Boisvert
      Pages 29-49

    3. Pre-mRNA Splicing and Disease

      • Michael R. Ladomery, Sebastian Oltean
      Pages 51-69

    4. Acute Promyelocytic Leukaemia: Epigenetic Function of the PML-RARα Oncogene

      • Julia P. Hofmann, Paolo Salomoni
      Pages 71-98

  4. Chromosomes

    1. Front Matter

      Pages 99-99
      Download chapter PDF

    2. Spatial Genome Organization and Disease

      • Karen J. Meaburn, Bharat Burman, Tom Misteli
      Pages 101-125

    3. Telomeres and Chromosome Stability

      • Tsz Wai Chu, Chantal Autexier
      Pages 127-154

  5. Nuclear Domains and Development

    1. Front Matter

      Pages 155-155
      Download chapter PDF

    2. Polycomb Bodies

      • Vincenzo Pirrotta
      Pages 157-173

    3. The Continuing Flight of Ikaros

      • Karen E. Brown
      Pages 175-202

  6. Nuclear Domains and Cell Stress

    1. Front Matter

      Pages 203-203
      Download chapter PDF

    2. Senescence Associated Heterochromatic Foci: SAHF

      • Tamir Chandra
      Pages 205-218

    3. DNA Repair Foci Formation and Function at DNA Double-Strand Breaks

      • Michael J. Hendzel, Hilmar Strickfaden
      Pages 219-237

    4. Nuclear Domains and DNA Repair

      • Jordan Pinder, Alkmini Kalousi, Evi Soutoglou, Graham Dellaire
      Pages 239-257

    5. The Interplay Between Inflammatory Signaling and Nuclear Structure and Function

      • Sona Hubackova, Simona Moravcova, Zdenek Hodny
      Pages 259-282

    6. Manipulation of PML Nuclear Bodies and DNA Damage Responses by DNA Viruses

      • Lori Frappier
      Pages 283-312

  7. Macromolecular Dynamics Within the Nucleus

    1. Front Matter

      Pages 313-313
      Download chapter PDF
Back to top

Keywords

About this book

This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.

Editors and Affiliations

  • Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada

    David P. Bazett-Jones

  • Dalhousie University, Halifax, Canada

    Graham Dellaire

About the editors

David P. Bazett-Jones
The Hospital for Sick Children, Toronto, ON, Canada 


                
Graham Dellaire
Dalhousie University, Halifax, NS, Canada

Bibliographic Information

  • Book Title: The Functional Nucleus

  • Editors: David P. Bazett-Jones, Graham Dellaire

  • DOI: https://doi.org/10.1007/978-3-319-38882-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-38880-9Published: 25 October 2016

  • Softcover ISBN: 978-3-319-81768-2Published: 23 June 2018

  • eBook ISBN: 978-3-319-38882-3Published: 17 October 2016

  • Edition Number: 1

  • Number of Pages: VI, 513

  • Number of Illustrations: 8 b/w illustrations, 48 illustrations in colour

  • Topics: Nucleic Acid Chemistry, Cell Biology, Cytogenetics

Publish with us

Policies and ethics

Back to top

Search

Navigation