Springer Theses

Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds

Authors: McDonald, Stacey L.

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  • Nominated as an outstanding PhD thesis by Duke University
  • Provides a comprehensive review of electrophilic aminations using O-benzoylhydroxylamines
  • Presents results which are relevant for medicinal chemistry, drug discovery and materials science
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  • ISBN 978-3-319-38878-6
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Hardcover $139.99
price for USA in USD
  • ISBN 978-3-319-38877-9
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Softcover $119.99
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  • ISBN 978-3-319-81767-5
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About this book

This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy.  McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.

The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.

McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. 

About the authors

Born and raised in South Carolina, Stacey McDonald completed her B.S. in Chemistry from Wofford College in 2009. She then matriculated into the Chemistry Department at Duke University to pursue her Ph.D. in Organic Chemistry. While at Duke, Stacey's research focused on organic synthesis and methodology development for electrophilic aminations. She successfully defended her Ph.D. in March 2015. Stacey is currently working as a Postdoctoral Fellow at the University of North Carolina - Chapel Hill in the lab of Jeff Aubé.

Table of contents (4 chapters)

Table of contents (4 chapters)
  • Electrophilic Amination for the Synthesis of Alkyl and Aryl Amines

    Pages 1-23

    McDonald, Stacey L.

  • Selective α-Amination and α-Acylation of Esters and Amides via Dual Reactivity of

    Pages 25-60

    McDonald, Stacey L.

  • Copper-Catalyzed α-Amination of Phosphonates and Phosphine Oxides: A Direct Approach to α-Amino Phosphonic Acids and Derivatives

    Pages 61-95

    McDonald, Stacey L.

  • Copper-Catalyzed Electrophilic Amination of Heteroarenes and Arenes by C–H Zincation

    Pages 97-142

    McDonald, Stacey L.

Buy this book

eBook $89.00
price for USA in USD
  • ISBN 978-3-319-38878-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.99
price for USA in USD
  • ISBN 978-3-319-38877-9
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
Softcover $119.99
price for USA in USD
  • ISBN 978-3-319-81767-5
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds
Authors
Series Title
Springer Theses
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-38878-6
DOI
10.1007/978-3-319-38878-6
Hardcover ISBN
978-3-319-38877-9
Softcover ISBN
978-3-319-81767-5
Series ISSN
2190-5053
Edition Number
1
Number of Pages
XXIII, 144
Number of Illustrations
8 b/w illustrations
Topics