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Springer Series in Pharmaceutical Statistics

Group Sequential and Confirmatory Adaptive Designs in Clinical Trials

Authors: Wassmer, Gernot, Brannath, Werner

  • Provides up-to-date ​overview of group sequential and confirmatory adaptive designs in clinical trials
  • Supplemented with a discussion of practical applications
  • Describes available software products                         
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Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-319-32562-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.99
price for USA in USD
  • ISBN 978-3-319-32560-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.99
price for USA in USD
  • ISBN 978-3-319-81314-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book provides an up-to-date review of the general principles of and techniques for confirmatory adaptive designs. Confirmatory adaptive designs are a generalization of group sequential designs. With these designs, interim analyses are performed in order to stop the trial prematurely under control of the Type I error rate. In adaptive designs, it is also permissible to perform a data-driven change of relevant aspects of the study design at interim stages. This includes, for example, a sample-size reassessment, a treatment-arm selection or a selection of a pre-specified sub-population.

Essentially, this adaptive methodology was introduced in the 1990s. Since then, it has become popular and the object of intense discussion and still represents a rapidly growing field of statistical research. This book describes adaptive design methodology at an elementary level, while also considering designing and planning issues as well as methods for analyzing an adaptively planned trial. This includes estimation methods and methods for the determination of an overall p-value. Part I of the book provides the group sequential methods that are necessary for understanding and applying the adaptive design methodology supplied in Parts II and III of the book. The book contains many examples that illustrate use of the methods for practical application.

The book is primarily written for applied statisticians from academia and industry who are interested in confirmatory adaptive designs. It is assumed that readers are familiar with the basic principles of descriptive statistics, parameter estimation and statistical testing. This book will also be suitable for an advanced statistical course for applied statisticians or clinicians with a sound statistical background.

About the authors

Gernot Wassmer is an Adjunct Professor of Biostatistics at the Institute of Medical Statistics, University of Cologne, Germany. He received his PhD from the University of Munich, Germany in 1993, after which he was a Research Fellow at Munich’s Institute of Medical Statistics, at the Institute for Epidemiology, GSF Neuherberg, and at the Institute of Medical Statistics, University of Cologne. His major research interest is in the field of statistical procedures for group sequential and adaptive plans in clinical trials. He has been a member of independent data monitoring committees for international, multi-center trials in various therapeutic fields and also serves as a consultant for the pharmaceutical industry.

 

Werner Brannath is a Professor of Biostatistics at the Faculty of Mathematics and Informatics, University of Bremen, where he is also head of the biometry group at the Competence Center for Clinical Trials. He has extensive experience in the planning and analysis of clinical trials and has been a member of several independent data monitoring committees. His main research interests include adaptive and group sequential designs, as well as multiple testing. 

Reviews

“This is an up-to-date review of the general principles of, and techniques for, confirmatory adaptive designs. … Chapters are well illustrated with tables and figures for better understanding. … This is a valuable resource for clinicians and applied statisticians with a sound statistical background who are interested in confirmatory adaptive designs.” (Pooja Sethi, Doody's Book Reviews, October, 2016)


Table of contents (11 chapters)

  • Repeated Significance Tests

    Wassmer, Gernot (et al.)

    Pages 3-23

  • Procedures with Equally Sized Stages

    Wassmer, Gernot (et al.)

    Pages 25-62

  • Procedures with Unequally Sized Stages

    Wassmer, Gernot (et al.)

    Pages 63-81

  • Confidence Intervals, p-Values, and Point Estimation

    Wassmer, Gernot (et al.)

    Pages 83-100

  • Applications

    Wassmer, Gernot (et al.)

    Pages 101-130

Buy this book

eBook $109.00
price for USA in USD (gross)
  • ISBN 978-3-319-32562-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $139.99
price for USA in USD
  • ISBN 978-3-319-32560-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $139.99
price for USA in USD
  • ISBN 978-3-319-81314-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Group Sequential and Confirmatory Adaptive Designs in Clinical Trials
Authors
Series Title
Springer Series in Pharmaceutical Statistics
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-32562-0
DOI
10.1007/978-3-319-32562-0
Hardcover ISBN
978-3-319-32560-6
Softcover ISBN
978-3-319-81314-1
Series ISSN
2366-8695
Edition Number
1
Number of Pages
XVI, 301
Number of Illustrations
44 b/w illustrations
Topics