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J Wave Syndromes

Brugada and Early Repolarization Syndromes

Editors: Antzelevitch, Charles, Yan, Gan-Xin (Eds.)

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  • Provides comprehensive guidance on proper diagnosis of J wave syndromes
  • Demonstrates therapeutic options for the management of this syndrome
  • Identifies those individuals who are at risk and to design safe and effective treatments
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  • ISBN 978-3-319-31578-2
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  • ISBN 978-3-319-31576-8
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  • Immediate ebook access, if available*, with your print order
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Softcover $199.99
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  • ISBN 978-3-319-81068-3
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  • Usually dispatched within 3 to 5 business days.
About this book

This book delineates the state of the art of the diagnosis and treatment of J wave syndromes, as well as where future research needs to be directed. It covers basic science, translational and clinical aspects of these syndromes. The authors are leading experts in their respective fields, who have contributed prominently to the literature concerning these topics.

J wave syndromes are one of the hottest topics in cardiology today. Cardiac arrhythmias associated with Brugada syndrome (BrS) or an early repolarization (ER) pattern in the inferior or infero-lateral ECG leads are thought to be mechanistically linked to accentuation of transient outward current (Ito)-mediated J waves. Although BrS and ER syndrome (ERS) differ with respect to magnitude and lead location of abnormal J waves, they are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes. ERS is divided into three subtypes with the most severe, Type 3, displaying an ER pattern globally in the inferior, lateral and right precordial leads. BrS has been linked to mutations in 19 different genes, whereas ERS has been associated with mutations in 7 different genes.

There is a great deal of confusion as to how to properly diagnose and treat the J wave syndromes as well as confusion about the underlying mechanisms. The demonstration of successful epicardial ablation of BrS has provided new therapeutic options for the management of this syndrome for which treatment alternatives are currently very limited, particularly in the case of electrical storms caused by otherwise uncontrollable recurrent VT/VF. An early repolarization pattern is observed in 2-5% of the US population. While it is clear that the vast majority of individuals exhibiting an ER pattern are not at risk for sudden cardiac death, the challenge moving forward is to identify those individuals who truly are at risk and to design safe and effective treatments.

About the authors

Dr Antzelevitch is Professor and Executive Director of Cardiovascular Research at the Lankenau Institute for Medical Research and Director of Research at Lankenau Heart Institute in Wynnewood, PA.  Awards include the Distinguished Scientist Award from the North American Society of Pacing and Electrophysiology (Heart Rhythm Society), Carl J. Wiggers Award of the American Physiological Society, the Distinguished Scientist Award of the American College of Cardiology and the Distinguished Service Award of the Cardiac Electrophysiology Society.  He has published over 510 original papers and reviews and seven books.  He is currently Associate Editor of the Heart Rhythm journal and Secretary-Treasurer of the Cardiac Electrophysiology Society.

Table of contents (16 chapters)

Table of contents (16 chapters)
  • History of the J Wave and J Wave Syndromes

    Pages 1-14

    Gussak, Ihor, MD, PhD, FACC (et al.)

  • J Wave Syndromes: From Bench to Bedside

    Pages 15-32

    Yan, Gan-Xin, MD, PhD. (et al.)

  • Ionic and Cellular Mechanisms Underlying J Wave Syndromes

    Pages 33-76

    Antzelevitch, Charles, PhD (et al.)

  • Genetic Basis of Early Repolarization Syndrome

    Pages 77-90

    Horie, Minoru, MD, PhD (et al.)

  • J Wave Syndrome-Susceptibility Mutations Versus Benign Rare Variants: How Do We Decide?

    Pages 91-120

    Kapplinger, Jamie D., BA (et al.)

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-3-319-31578-2
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-3-319-31576-8
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $199.99
price for USA in USD
  • ISBN 978-3-319-81068-3
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
J Wave Syndromes
Book Subtitle
Brugada and Early Repolarization Syndromes
Editors
  • Charles Antzelevitch
  • Gan-Xin Yan
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-31578-2
DOI
10.1007/978-3-319-31578-2
Hardcover ISBN
978-3-319-31576-8
Softcover ISBN
978-3-319-81068-3
Edition Number
1
Number of Pages
XV, 327
Number of Illustrations
43 b/w illustrations, 48 illustrations in colour
Topics

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