Advances in Experimental Medicine and Biology

Cancer and Zebrafish

Mechanisms, Techniques, and Models

Editors: Langenau, David M. (Ed.)

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  • Provides the most up-to-date research on zebrafish models for oncogene and tumor suppressor discovery
  • Explores potential drug targets in various cancers, including leukemia, melanoma, pancreatic and liver cancers
  • Reviews allograft cell transplantation and xenograft transplantation in zebrafish  
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eBook $189.00
price for USA in USD (gross)
  • ISBN 978-3-319-30654-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-319-30652-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-3-319-80860-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system.

About the authors

Dr. Langenau is an Associate Professor at Harvard Medical School and Associate Pathologist at the Massachusetts General Hospital.  Dr. Langenau is joint-appointed through the Department of Pathology, the Cancer Center and the Center for Regenerative Medicine at the Massachusetts General Hospital. Dr. Langenau is also a principal faculty member at the Harvard Stem Cell Institute (HSCI) and a member of the Dana-Farber/Harvard Cancer Center. Dr. Langenau runs an active research group that focuses on uncovering mechanisms of progression and relapse in pediatic cancer.  He has become a pioneer in using zebrafish to understand human cancer biology. His group has used the zebrafish model to dynamically visualize the hallmarks of cancer in live animals, to develop drug screening approaches to kill relapse-driving tumor propagating cells, and to uncover oncogenic drivers conserved in zebrafish and humans using bioinformatic approaches and cross-species comparisons.

Table of contents (23 chapters)

Table of contents (23 chapters)
  • Uncharted Waters: Zebrafish Cancer Models Navigate a Course for Oncogene Discovery

    Ceol, Craig J. (et al.)

    Pages 3-19

  • The Toolbox for Conditional Zebrafish Cancer Models

    Mayrhofer, Marie (et al.)

    Pages 21-59

  • Approaches to Inactivate Genes in Zebrafish

    Parant, John M. (et al.)

    Pages 61-86

  • Tumor Suppressors in Zebrafish: From TP53 to PTEN and Beyond

    Hertog, Jeroen

    Pages 87-101

  • Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish

    Dang, Michelle (et al.)

    Pages 103-124

Buy this book

eBook $189.00
price for USA in USD (gross)
  • ISBN 978-3-319-30654-4
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $249.99
price for USA in USD
  • ISBN 978-3-319-30652-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $249.99
price for USA in USD
  • ISBN 978-3-319-80860-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cancer and Zebrafish
Book Subtitle
Mechanisms, Techniques, and Models
Editors
  • David M. Langenau
Series Title
Advances in Experimental Medicine and Biology
Series Volume
916
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-30654-4
DOI
10.1007/978-3-319-30654-4
Hardcover ISBN
978-3-319-30652-0
Softcover ISBN
978-3-319-80860-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XII, 552
Number of Illustrations
85 illustrations in colour
Topics