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  • Book
  • © 2016

Cancer and Zebrafish

Mechanisms, Techniques, and Models

Editors:

  1. David M. Langenau

    1. Molecular Pathology and Cancer Center, Massachusetts General Hospital, CHARLESTOWN, USA

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  • Provides the most up-to-date research on zebrafish models for oncogene and tumor suppressor discovery
  • Explores potential drug targets in various cancers, including leukemia, melanoma, pancreatic and liver cancers
  • Reviews allograft cell transplantation and xenograft transplantation in zebrafish
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 916)

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xii
    PDF

  2. Powers of the Zebrafish Model

    1. Front Matter

      Pages 1-1
      PDF

    3. The Toolbox for Conditional Zebrafish Cancer Models

      • Marie Mayrhofer, Marina Mione
      Pages 21-59

    4. Approaches to Inactivate Genes in Zebrafish

      • John M. Parant, Jing-Ruey Joanna Yeh
      Pages 61-86

    6. Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish

      • Michelle Dang, Rachel Fogley, Leonard I. Zon
      Pages 103-124

    7. Genomic Approaches to Zebrafish Cancer

      • Richard M. White
      Pages 125-145

    8. Transcriptomic Analyses in Zebrafish Cancer Models for Global Gene Expression and Pathway Discovery

      • Xiaoqian Huang, Ira Agrawal, Zhen Li, Weiling Zheng, Qingsong Lin, Zhiyuan Gong
      Pages 147-168

    9. Zebrafish Discoveries in Cancer Epigenetics

      • Yelena Chernyavskaya, Brandon Kent, Kirsten C. Sadler
      Pages 169-197

    10. Lymphatics, Cancer and Zebrafish

      • Jonathan W. Astin, Philip S. Crosier
      Pages 199-218

    11. In Vivo Imaging of Cancer in Zebrafish

      • Myron S. Ignatius, Madeline Hayes, David M. Langenau
      Pages 219-237

    12. Imaging Cancer Angiogenesis and Metastasis in a Zebrafish Embryo Model

      • C. Tulotta, S. He, W. van der Ent, L. Chen, A. Groenewoud, H. P. Spaink et al.
      Pages 239-263

    13. Allograft Cancer Cell Transplantation in Zebrafish

      • John C. Moore, David M. Langenau
      Pages 265-287

    14. The Zebrafish Xenograft Platform: Evolution of a Novel Cancer Model and Preclinical Screening Tool

      • Jaime Wertman, Chansey J. Veinotte, Graham Dellaire, Jason N. Berman
      Pages 289-314

    15. Automation of Technology for Cancer Research

      • Wietske van der Ent, Wouter J. Veneman, Arwin Groenewoud, Lanpeng Chen, Claudia Tulotta, Pancras C. W. Hogendoorn et al.
      Pages 315-332

  3. Cancer Models in Fish

    1. Front Matter

      Pages 333-333
      PDF

    2. Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights

      • Nicholas R. Harrison, Fabrice J. F. Laroche, Alejandro Gutierrez, Hui Feng
      Pages 335-369

    3. Zebrafish Rhabdomyosarcoma

      • Michael Phelps, Eleanor Chen
      Pages 371-389
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About this book

This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system.
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Keywords

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Editors and Affiliations

  • Molecular Pathology and Cancer Center, Massachusetts General Hospital, CHARLESTOWN, USA

    David M. Langenau

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About the editor

Dr. Langenau is an Associate Professor at Harvard Medical School and Associate Pathologist at the Massachusetts General Hospital.  Dr. Langenau is joint-appointed through the Department of Pathology, the Cancer Center and the Center for Regenerative Medicine at the Massachusetts General Hospital. Dr. Langenau is also a principal faculty member at the Harvard Stem Cell Institute (HSCI) and a member of the Dana-Farber/Harvard Cancer Center. Dr. Langenau runs an active research group that focuses on uncovering mechanisms of progression and relapse in pediatic cancer.  He has become a pioneer in using zebrafish to understand human cancer biology. His group has used the zebrafish model to dynamically visualize the hallmarks of cancer in live animals, to develop drug screening approaches to kill relapse-driving tumor propagating cells, and to uncover oncogenic drivers conserved in zebrafish and humans using bioinformatic approaches and cross-species comparisons.
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Bibliographic Information

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Buy it now

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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