Progress in Inflammation Research

Autophagy Networks in Inflammation

Editors: Maiuri, Maria Chiara, De Stefano, Daniela (Eds.)

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  • Covers the molecular mechanisms underlying autophagy in inflammation
  • Discusses opportunities to target autophagy as a novel therapeutic strategy against inflammation-based diseases
  • Provides an overview on clinical trials
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About this book

Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.

Buy this book

eBook n/a
  • ISBN 978-3-319-30079-5
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
Hardcover n/a
  • ISBN 978-3-319-30077-1
  • Free shipping for individuals worldwide
Softcover n/a
  • ISBN 978-3-319-80719-5
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Autophagy Networks in Inflammation
Editors
  • Maria Chiara Maiuri
  • Daniela De Stefano
Series Title
Progress in Inflammation Research
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-30079-5
DOI
10.1007/978-3-319-30079-5
Hardcover ISBN
978-3-319-30077-1
Softcover ISBN
978-3-319-80719-5
Series ISSN
0379-0363
Edition Number
1
Number of Pages
XV, 403
Number of Illustrations
4 b/w illustrations, 16 illustrations in colour
Topics