Novel Immunotherapeutic Approaches to the Treatment of Cancer

Drug Development and Clinical Application

Editors: Rennert, Paul D. (Ed.)

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  • Chapters not only cover current progress but anticipate the evolution of cancer treatment across diverse Immune Therapeutic approaches
  • Covers the varied, diverse aspects of the term "immunotherapy"
  • Addresses the medical application of the various immunotherapies
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Softcover $199.99
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  • ISBN 978-3-319-80662-4
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About this book

Cancer care is undergoing a radical transformation as novel technologies are directed toward new treatments and personalized medicine. The most dramatic advances in the treatment of cancer have come from therapeutics that augment the immune response to tumors. The immune checkpoint inhibitors are the best-known and most highly advanced examples of Immune Therapeutics targeting tumor cells and include approved antibody drugs directed at the cell surface proteins CTLA4 and PD-1. These are now considered foundational treatments for several solid tumor indications, and that list of indications is growing quickly. More broadly, antibodies have become workhorse molecules across the entire immunotherapy landscape. Antibodies to novel targets modulate the activity of diverse immune cell regulatory proteins. Engineered antibodies can induce tumor cell death or expose tumor cells to poisonous toxins (ADCC and ADC, respectively). Bi-specific antibodies can engage multiple tumor targets simultaneously, or can redirect lymphocytes to attack tumor cells. The antigen-binding domains within antibodies can be spliced onto cell stimulatory domains and transduced into T cells or NK cells, creating remarkable tumor-specific cellular therapeutics (CAR-T, CAR-NK). Beyond antibody-based therapies there are highly diverse and differentiated technology tool kits being applied to immunotherapy. Small molecule drugs are being developed to attack the tumor microenvironment, novel tumor vaccine approaches are showing great promise, patient lymphocytes are being isolated, expanded and reintroduced to patients, gene-editing techniques are becoming widely deployed, and a vast number of new tumor targets, and mutated tumor proteins (neoantigens), are being discovered.

The past decade has seen unprecedented success in the treatment of diverse cancers. The authors of this volume have been asked to not only review progress to date, but importantly, to look ahead, and anticipate the evolution of cancer treatment across diverse Immune Therapeutic approaches. Our hypothesis is that the advances we are seeing across the immunotherapy landscape will further evolve and synergize, leading us finally to outright cures for many cancers.

 

About the authors

Paul D. Rennert, SugarCone Biotech LLC

Table of contents (10 chapters)

Table of contents (10 chapters)
  • Enhancing the Efficacy of Checkpoint Blockade Through Combination Therapies

    Juneja, Vikram R. (et al.)

    Pages 1-39

  • Novel Immunomodulatory Pathways in the Immunoglobulin Superfamily

    Rennert, Paul D.

    Pages 41-58

  • Parallel Costimulation of Effector and Regulatory T Cells by OX40, GITR, TNFRSF25, CD27, and CD137: Implications for Cancer Immunotherapy

    Schreiber, Taylor H.

    Pages 59-78

  • NK Cell Responses in Immunotherapy: Novel Targets and Applications

    Pachynski, Russell (et al.)

    Pages 79-108

  • Reversing T Cell Dysfunction for Tumor Immunotherapy

    Kane, Lawrence P. (et al.)

    Pages 109-128

Buy this book

eBook $149.00
price for USA in USD (gross)
  • ISBN 978-3-319-29827-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA in USD
  • ISBN 978-3-319-29825-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $199.99
price for USA in USD
  • ISBN 978-3-319-80662-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Novel Immunotherapeutic Approaches to the Treatment of Cancer
Book Subtitle
Drug Development and Clinical Application
Editors
  • Paul D. Rennert
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-29827-6
DOI
10.1007/978-3-319-29827-6
Hardcover ISBN
978-3-319-29825-2
Softcover ISBN
978-3-319-80662-4
Edition Number
1
Number of Pages
XI, 276
Number of Illustrations
25 illustrations in colour
Topics