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Vascular Ion Channels in Physiology and Disease

Editors: Levitan, PhD, Irena, Dopico, MD, PhD, Alex M. (Eds.)

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  • Presents the studies undertaken in the last decade to elucidate the roles of ion channels in different vascular diseases
  • Focuses on the roles of ion channels in vascular tissues under normal and pathological condition
  • Written by experts in the field
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eBook $169.00
price for USA in USD (gross)
  • ISBN 978-3-319-29635-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-3-319-29633-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-3-319-80613-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions.  Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.

About the authors

Alex Dopico, PhD, MD, is Chair of Pharmacology and Distinguished Professor at the University of Tennessee Health Science Center, Memphis, Tennessee.  His research interest focuses on the molecular interactions between small amphiphilic ligands, such as alcohol, and oligomeric ion channel proteins in excitable tissues, with a particular focus on cerebral artery smooth muscle.  Emphasis is put on determining site(s) of action and ion channel gating mechanisms targeted by the amphiphiles, role of membrane lipid microenvironment in regulating ligand-ion channel interaction, and consequences of such interaction on tissue and organ function.  Dr. Dopico currently holds a Merit Award from NIAAA, and also served as editor of the book Methods in Membrane Lipids published by Humana in 2007.

Irena Levitan, PhD, is a Professor of Medicine and Adjunct Professor of Pharmacology and Bioengineering at the University of Illinois at Chicago. Her current research interests focus on cholesterol regulation of ion channels and cellular biomechanics. She was named a Guyton Distinguished Lecturer by the Association of Chairs of Departments of Physiology for her quantitative and biophysical work on cholesterol modulation of ion channels and how this can affect integrated organ function. She also served as editor of the book Cholesterol Regulation of Ion Channels and Receptors, published by Wiley in 2012.

Table of contents (19 chapters)

Table of contents (19 chapters)
  • Endothelial Cell Ion Channel Expression and Function in Arterioles and Resistance Arteries

    Pages 3-36

    Jackson, William F.

  • Contribution and Regulation of Calcium Channels in Endothelial Cells

    Pages 37-62

    Cheng, Kwong Tai (et al.)

  • Mitochondrial Depolarization in Endothelial and Other Vascular Cells and Their Role in the Regulation of Cerebral Vascular Tone

    Pages 63-78

    Busija, David W., Ph.D., M.D. [Hon] (et al.)

  • Ion Channels in Control of Blood Flow: Electrical Conduction Along Endothelium of Resistance Arteries

    Pages 79-99

    Behringer, Erik J. (et al.)

  • Ca2+/Calmodulin-Gated Small- and Intermediate-Conductance KCa Channels in Cardiovascular Regulation: Targets for Novel Pharmacological Treatments

    Pages 101-127

    Köhler, Ralf (et al.)

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-3-319-29635-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $219.99
price for USA in USD
  • ISBN 978-3-319-29633-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $219.99
price for USA in USD
  • ISBN 978-3-319-80613-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Vascular Ion Channels in Physiology and Disease
Editors
  • Irena Levitan, PhD
  • Alex M. Dopico, MD, PhD
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-29635-7
DOI
10.1007/978-3-319-29635-7
Hardcover ISBN
978-3-319-29633-3
Softcover ISBN
978-3-319-80613-6
Edition Number
1
Number of Pages
XVII, 431
Number of Illustrations
28 b/w illustrations, 75 illustrations in colour
Topics