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Current Clinical Pathology

Radiobiology of Glioblastoma

Recent Advances and Related Pathobiology

Editors: Pirtoli, Luigi, Gravina, Giovanni Luca, Giordano, Antonio (Eds.)

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  • Provides the most recent and relevant advances in molecular radiobiology of glioblastoma, and the related possible changes in the clinical setting 
  • Written by experts in the field 
  • Bridges the gap of knowledge and methodology in approaching RB of GB between basic researchers and clinical investigators
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eBook $89.00
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  • ISBN 978-3-319-28305-0
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Hardcover $149.99
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  • ISBN 978-3-319-28303-6
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Softcover $119.99
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  • ISBN 978-3-319-80321-0
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About this book

This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models. 

Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators. 


About the authors

Dr. Luigi PirtoliRadiation Oncology UnitDepartment of Medicine, Surgery and NeurosciencesUniversity of SienaSiena, Italy
Dr. Giovanni Luca GravinaDepartment of Biology and BiotechnologyUniversity of PaviaRome, Italy
Antonio GiordanoSbarro Institute for Cancer Research and Molecular Medicine and Center for BiotechnologyTemple UniversityPhiladelphia, PA, USADepartment of Medicine, Surgery & NeurosciencesUniversity of SienaSiena, Italy

Reviews

“This is a very detailed monograph on the roles of radiation, immunotherapy, genetic, epigenetic, and chemotherapy in the treatment of Glioblastoma. Biomarkers and molecular mechanisms of GBMs are discussed. … I highly recommend this book to oncologists, neurosurgeons, neurologists, and researchers involved in this perplexing baffling tumor.” (Joseph Grenier, Amazon.com, May, 2018)

Table of contents (19 chapters)

Table of contents (19 chapters)
  • Introduction and Background

    Pages 1-11

    Pirtoli, Luigi (et al.)

  • The “Radioresistance” of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options

    Pages 15-27

    Buglione, Michela (et al.)

  • Radiobiological Hints from Clinical Studies

    Pages 29-40

    Scoccianti, Silvia (et al.)

  • Chemoradiotherapy: Radiation Total Dose and Fractionation

    Pages 41-62

    Chiesa, Silvia (et al.)

  • Clinical Evidence and Radiobiological Background of Particle Radiation Therapy

    Pages 63-85

    Tinganelli, Walter (et al.)

Buy this book

eBook $89.00
price for USA in USD
  • ISBN 978-3-319-28305-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $149.99
price for USA in USD
  • ISBN 978-3-319-28303-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
Softcover $119.99
price for USA in USD
  • ISBN 978-3-319-80321-0
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Radiobiology of Glioblastoma
Book Subtitle
Recent Advances and Related Pathobiology
Editors
  • Luigi Pirtoli
  • Giovanni Luca Gravina
  • Antonio Giordano
Series Title
Current Clinical Pathology
Copyright
2016
Publisher
Humana Press
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-28305-0
DOI
10.1007/978-3-319-28305-0
Hardcover ISBN
978-3-319-28303-6
Softcover ISBN
978-3-319-80321-0
Series ISSN
2197-781X
Edition Number
1
Number of Pages
XX, 305
Number of Illustrations
10 b/w illustrations, 39 illustrations in colour
Topics

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