Overview
- Updated state-of-the-art information on biopharmaceutic, pharmacokinetic, and pharmacodynamic modeling
- New chapters on Bioequivalence and Fractional Pharmacokinetics, contributed by leaders in the field
- New sections on time-varying models and interface models
- Appeals to both graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology
- Covers the theory with specific examples behind all three under the perspective of heterogeneous processes while also treating the current state of the art in applied and theoretical BPP
Part of the book series: Interdisciplinary Applied Mathematics (IAM, volume 30)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (15 chapters)
-
Front Matter
-
Basic Concepts
-
Front Matter
-
-
Modeling in Biopharmaceutics
-
Front Matter
-
-
Modeling in Pharmacokinetics
-
Front Matter
-
-
Modeling in Pharmacodynamics
-
Front Matter
-
Keywords
About this book
The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body.
The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with epirical, compartmental, and stochastic pharmacokinetic models, with two new chapters, one on fractional pharmacokinetics and one on bioequivalence; and the fourth mainly with classical and nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. This second edition has new information on reaction limited models of dissolution, non binary biopharmaceutic classification system, time varying models, and interface models. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.
This book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology.
Reviews of the first edition:
"This book presents a novel modelling approach to biopharmaceutics, pharmacokinetics and pharmacodynamic phenomena. This state-of-the-art volume will be helpful to students and researchers in pharmacology, bioengineering, and physiology. This book is a must for pharmaceutical researchers to keep up with recent developments in this field." (P. R. Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007)
"These authors are the unique (or sole) contributors in this area that are working on these questions and bring a special expertise to the field that is now being recognized as essential to understanding biological system and kinetic/dynamic characteristics in drug development...This text is an essential primer for those who would envision the incorporation of heterogeneous approaches to systems where homogeneous approaches are not sufficient to describe the system." (Robert R. Bies, Journal of Clinical Pharmacology, Vol. 46, 2006)
Authors and Affiliations
Bibliographic Information
Book Title: Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics
Book Subtitle: Homogeneous and Heterogeneous Approaches
Authors: Panos Macheras, Athanassios Iliadis
Series Title: Interdisciplinary Applied Mathematics
DOI: https://doi.org/10.1007/978-3-319-27598-7
Publisher: Springer Cham
eBook Packages: Mathematics and Statistics, Mathematics and Statistics (R0)
Copyright Information: Springer International Publishing Switzerland 2016
Hardcover ISBN: 978-3-319-27596-3Published: 19 April 2016
Softcover ISBN: 978-3-319-80181-0Published: 22 April 2018
eBook ISBN: 978-3-319-27598-7Published: 30 March 2016
Series ISSN: 0939-6047
Series E-ISSN: 2196-9973
Edition Number: 2
Number of Pages: XXII, 483
Number of Illustrations: 156 b/w illustrations, 1 illustrations in colour
Topics: Mathematical and Computational Biology, Pharmacology/Toxicology, Biological and Medical Physics, Biophysics, Biomedical Engineering and Bioengineering, Biochemistry, general, Applications of Mathematics